NCT07219680: Multi-PA

Intervention to Promote Communication Quality of Life for Persons With Language-Led Dementia and Their Partners: A Randomized Pilot Trial

Recruiting now NA Last updated 15 April 2026

What this trial tests

NA trial testing Multicomponent Lexical Retrieval Cascade Training in Primary Progressive Aphasia(PPA) in 30 participants. Currently enrolling.

Timeline

1 April 2026

Primary endpoint
1 August 2027

1 August 2027

Quick facts

Lead sponsor	Maya Henry
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	30
Start date	1 April 2026
Primary completion	1 August 2027
Estimated completion	1 August 2027
Sites	1 location across United States

Drugs / interventions tested

• Multicomponent Lexical Retrieval Cascade Training
• Multicomponent Video Implemented Script Training in Aphasia

Conditions studied

• Primary Progressive Aphasia(PPA) — all drugs for Primary Progressive Aphasia(PPA) →
• Semantic Dementia — all drugs for Semantic Dementia →
• Logopenic Progressive Aphasia (LPA) — all drugs for Logopenic Progressive Aphasia (LPA) →
• Nonfluent Aphasia, Progressive — all drugs for Nonfluent Aphasia, Progressive →

Sponsor

Maya Henry

Who can join

40 and older, any sex, with Primary Progressive Aphasia(PPA) or Semantic Dementia. Patients with the condition only — healthy volunteers not accepted.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

• Change in spoken naming of trained/untrained items
  Time frame: change from pre-treatment or waitlist to post-treatment or waitlist (12-13 weeks), and follow-up at 3 months post-treatment
  Percent correctly named trained/untrained pictures
• Change in script production accuracy
  Time frame: change from pre-treatment or waitlist to post-treatment or waitlist (12-13 weeks), and follow-up at 3 months post-treatment
  Percent correct intelligible, scripted words for trained/untrained scripts
• Change in barriers and facilitators in dyad conversation
  Time frame: change from pre-treatment or waitlist to post-treatment or waitlist (12-13 weeks), and follow-up at 3 months post-treatment
  Number of conversation barriers and facilitators observed in conversation
• Communication Modality Inventory
  Time frame: change from pre-treatment or waitlist to post-treatment or waitlist (12-13 weeks), and follow-up at 3 months post-treatment
  A likert-type survey characterizing frequency and type of communication modalities used in conversation, administered to both the person with PPA and their conversation partner.

Sponsor's own description

The goal of this clinical trial is to learn whether a personalized, multi-component, virtual speech language treatment program can improve communication and quality of life for adults with primary progressive aphasia (PPA) and their primary communication partners. The study will enroll participants who speak English and/or Spanish.

The main questions the study aims to answer are:

* Is the telerehabilitation program feasible and acceptable for people with PPA and their study partners?
* Do participants with PPA and study partners find treatment beneficial?
* What patterns of treatment response are seen in participants?
* Which outcome measures are most useful for evaluating changes in communication and quality of life?

Researchers will compare participants who receive intervention immediately to participants assigned to a waitlist control group (who will receive treatment after a delay) to see whether participation in the treatment program is associated with improvements in communication and quality of life.

Participants will:

* Take part in speech language therapy sessions delivered by video visit that combine restorative, compensatory, and partner-focused communication strategies. Treatment may take place after a waiting period.
* Receive education and communication training together with their partner.
* Complete speech, language, and cognitive assessments.
* Complete questionnaires about communication abilities, daily functioning, and quality of life.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.