NCT07216209

The Impact of Exercise on the Tumor Microenvironment in Patients With Lung Cancer

Not yet recruiting NA Last updated 22 October 2025

What this trial tests

NA trial testing EXERCISE TRAINING WITH OR WITHOUT MEDICATION in Lung Cancer - Non Small Cell in 48 participants. Not yet recruiting.

Timeline

20 November 2025

Primary endpoint
15 January 2030

15 January 2030

Quick facts

Lead sponsor	University of Arizona
Phase	NA
Status	Not yet recruiting
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	prevention
Enrollment	48
Start date	20 November 2025
Primary completion	15 January 2030
Estimated completion	15 January 2030
Sites	1 location across United States

Drugs / interventions tested

• EXERCISE TRAINING WITH OR WITHOUT MEDICATION — full drug profile →

Conditions studied

• Lung Cancer - Non Small Cell — all drugs for Lung Cancer - Non Small Cell →

Sponsor

University of Arizona

Who can join

18 and older, any sex, with Lung Cancer - Non Small Cell. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

There is increased interest and knowledge about the lung cancer tumor microenvironment (TME). Investigators hypothesize that patients with better baseline physiologic health will have better post-operative outcomes and that strenuous exercise will alter the TME and genetic make-up of the tumor, improving the tumor immune response. Investigators aim to identify the peri-operative and clinical outcomes that differ based on pre-operative VO2max, HRV and resting heart rate following resection of early-stage lung cancer. The physiologic states that are individual and measurable with wearable devices include but are not limited to VO2max, heart rate variability (HRV), and average resting heart rate. Investgators hypothesize that a patient's pre-operative physiologic function with higher VO2max, HRV and lower resting heart rate will be associated with improved peri-operative and post-operative outcomes. Second, investigators will compare alterations in TME based on targeted pre-operative exercise (60-80% of their VO2 max for 75min/week x2 weeks) compared to normal activity adults following resection of early-stage lung cancer. Investigators hypothesize that strenuous exercise in the pre-operative period will impact the TME by increasing levels of cytokines.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.