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NCT07214558: DNA-TKA
Spinal Versus General Anesthesia and Inflammatory Response Measured by Delta Neutrophil Index in Total Knee Arthroplasty: An Observational Study
trial testing Routine Clinical Anesthesia Practice in Inflammatory Response in Total Knee Arthroplasty in 84 participants. Completed in 22 October 2025.
22 October 2025
Quick facts
| Lead sponsor | Elazıg Fethi Sekin Sehir Hastanesi |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 84 |
| Start date | 22 September 2025 |
| Primary completion | 22 October 2025 |
| Estimated completion | 22 October 2025 |
| Sites | 1 location across Turkey (Türkiye) |
Drugs / interventions tested
- Routine Clinical Anesthesia Practice
Conditions studied
- Inflammatory Response in Total Knee Arthroplasty — all drugs for Inflammatory Response in Total Knee Arthroplasty →
Sponsor
Elazıg Fethi Sekin Sehir Hastanesi — full company profile →
Who can join
Adults 18 to 99, any sex, with Inflammatory Response in Total Knee Arthroplasty. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study aims to compare the effects of spinal versus general anesthesia on the inflammatory response measured by Delta Neutrophil Index (DNI) in patients undergoing total knee arthroplasty. The study is prospective and observational. A total of at least 84 patients will be included, with anesthesia type determined according to routine clinical practice. Preoperative and postoperative blood tests will be analyzed, and no additional blood samples will be required.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT07214558
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07214558 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Elazıg Fethi Sekin Sehir Hastanesi
- Last refreshed: 26 November 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07214558.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing