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NCT07212465: NACC-D
Accelerated Neuromodulation of Anterior Cingulate Cortex for Depression
NA trial testing Active Brainsway H7-Coil Deep TMS System in Major Depressive Disorder (MDD) in 24 participants. Currently enrolling.
1 January 2027
Quick facts
| Lead sponsor | Rotman Research Institute at Baycrest |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 24 |
| Start date | 21 July 2025 |
| Primary completion | 1 January 2027 |
| Estimated completion | 15 February 2027 |
| Sites | 1 location across Canada |
Drugs / interventions tested
- Active Brainsway H7-Coil Deep TMS System
- Sham Brainsway H1-Coil Deep TMS System
Conditions studied
- Major Depressive Disorder (MDD) — all drugs for Major Depressive Disorder (MDD) →
Sponsor
Rotman Research Institute at Baycrest
Who can join
Adults 60 to 85, any sex, with Major Depressive Disorder (MDD). Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this clinical trial is to test whether an accelerated deep Transcranial Magnetic Stimulation (dTMS) protocol can reduce depressive symptoms in older adults (ages 60-85) with Major Depressive Disorder (MDD) who have not tolerated or responded to antidepressant medications. The study will evaluate whether accelerated dTMS administered over 5 consecutive days is safe and well-tolerated in this population, and whether it produces greater reductions in depressive symptoms compared to placebo stimulation.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07212465
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Active Brainsway H7-Coil Deep TMS System
Trials testing the same drug.
- NCT07212504 — Effect of Accelerated Neuromodulation of Anterior Cingulate Cortex to Enhance Cognition in Older Adults With Mild Memory · NA · recruiting
- NCT06095063 — dTMS for Subjective Cognitive Decline · NA · recruiting
Other recruiting trials for Major Depressive Disorder (MDD)
Currently open trials in the same condition.
- NCT07396272 — A Clinical Trial of Add-on Oral Slow-release Ketamine Treatment in Major Depression · Phase 2 · recruiting
- NCT07226661 — Double-blind, Placebo-controlled Study in Adults With Major Depressive Disorder · Phase 2 · recruiting
- NCT07324070 — Electroconvulsive Therapy Augmented With Transcranial Magnetic Stimulation for Treatment Resistant Depression · NA · recruiting
- NCT06972368 — Home-Based tDCS for Depression in BPD · NA · recruiting
- NCT07294924 — Prediction of REsponse to Depression Interventions (Accelerated rTMS) Using Clinical and TD-fNIRS Measurements · recruiting
Other Rotman Research Institute at Baycrest trials
Trials by the same sponsor.
- NCT07212504 — Effect of Accelerated Neuromodulation of Anterior Cingulate Cortex to Enhance Cognition in Older Adults With Mild Memory · NA · recruiting
- NCT06095063 — dTMS for Subjective Cognitive Decline · NA · recruiting
- NCT05076045 — Effects of PSAPs on Speech Processing · NA · completed
- NCT04623125 — Spaced Retrieval as Treatment for Aphasia · NA · completed
- NCT03665831 — Deep TMS for Comorbid Depression and Cognitive Impairment in Older Adults · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07212465 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Rotman Research Institute at Baycrest
- Last refreshed: 28 October 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07212465.
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