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NCT07202312: PD-OZONE
Ozone-therapy in Non-surgical Periodontal Therapy
NA trial testing Ozone-therapy after non-surgical therapy in Ozone-therapy (O3) in 39 participants. Completed in 30 May 2024.
30 May 2024
Quick facts
| Lead sponsor | Universita di Verona |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 39 |
| Start date | 3 August 2023 |
| Primary completion | 30 May 2024 |
| Estimated completion | 30 May 2024 |
| Sites | 1 location across Italy |
Drugs / interventions tested
- Ozone-therapy after non-surgical therapy
Conditions studied
- Ozone-therapy (O3) — all drugs for Ozone-therapy (O3) →
- Periodontitis — all drugs for Periodontitis →
- Antimicrobial Ozone Therapy — all drugs for Antimicrobial Ozone Therapy →
Sponsor
Universita di Verona — full company profile →
Who can join
Adults 18 to 84, any sex, with Ozone-therapy (O3) or Periodontitis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Non-surgical periodontal therapy is a widely adopted procedure for the treatment of periodontitis, particularly in its moderate to severe stages. The approach involves the mechanical and manual debridement of subgingival biofilm and calculus through the use of ultrasonic scalers and hand curettes. This method aims to disrupt the pathogenic bacterial load within periodontal pockets and promote clinical attachment gain while reducing inflammation. However, the mechanical removal of biofilm alone may not always ensure complete bacterial eradication, especially in deep or anatomically complex sites. To enhance bacterial disinfection and optimize clinical outcomes, the adjunctive use of ozone therapy has been introduced. This is a non-invasive technique that employs ozone in gaseous form to eliminate bacteria and fungi, inactivate viruses, and control bleeding. Its antiviral efficacy results from the denaturation of envelope proteins, impairment of viral adhesion to host cells, oxidation of unsaturated fatty acids within the lipid envelope, and degradation of single-stranded RNA. The synergistic effect of combining conventional non-surgical periodontal therapy with ozone therapy enables more thorough decontamination of periodontal pockets, even in cases where systemic antibiotics prove ineffective. The aim of this study is to evaluate the clinical efficacy of adjunctive ozone therapy following non-surgical periodontal treatment in patients with severe periodontitis. The protocol consists of initial subgingival instrumentation using ultrasonic and manual tools, followed by the application of ozone therapy. The working hypothesis of this study is that the addition of ozone therapy provides superior bacterial reduction and improved clinical outcomes compared to mechanical therapy alone.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT07202312
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07202312 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Universita di Verona
- Last refreshed: 1 October 2025
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