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NCT07195201: CIP-ONLAY
Clinical Evaluation of Additive and Subtractive Onlay Restorations
NA trial testing 3D Printed Onlay Restoration in CAD-CAM in 29 participants. Not yet recruiting.
31 May 2027
Quick facts
| Lead sponsor | Ayse Tugba Erturk Avunduk |
|---|---|
| Phase | NA |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 29 |
| Start date | 15 November 2025 |
| Primary completion | 31 May 2027 |
| Estimated completion | 31 August 2027 |
| Sites | 1 location across Turkey (Türkiye) |
Drugs / interventions tested
- 3D Printed Onlay Restoration
- CAD/CAM Onlay Restoration
Conditions studied
- CAD-CAM — all drugs for CAD-CAM →
- Prospective Study — all drugs for Prospective Study →
- 3D Printing — all drugs for 3D Printing →
- Clinical Assessment — all drugs for Clinical Assessment →
Sponsor
Ayse Tugba Erturk Avunduk
Who can join
Adults 18 to 84, any sex, with CAD-CAM or Prospective Study. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this clinical trial is to learn whether onlay restorations produced by additive manufacturing \[three-dimensional (3D) printing\] and subtractive manufacturing \[Computer-Aided Design/Computer-Aided Manufacturing (CAD/CAM) milling\] perform equally well in vital posterior teeth. The main questions it aims to answer are: * Do 3D printed onlay restorations show similar marginal adaptation and clinical performance compared to CAD/CAM milled onlays? * Are there any differences in biological compatibility, surface properties, or postoperative sensitivity between the two techniques over time? Researchers will compare onlay restorations fabricated with 3D printing and CAD/CAM milling using a split-mouth study design. Participants will: * Receive one onlay restoration produced by 3D printing and another produced by CAD/CAM milling, placed on opposite sides of the mouth * Have checkups at baseline (1st week), 6 months, 12 months, and 18 months after treatment * Be evaluated using the Fédération Dentaire Internationale (FDI) criteria for marginal adaptation, surface quality, anatomical form, and biological compatibility
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07195201
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for CAD-CAM
Currently open trials in the same condition.
- NCT06442787 — Analysis of Mandibular Proximal Segment Position Using Virtual Orthognathic Surgical Planning, Individualized Guides, an · NA · recruiting
- NCT06589570 — Intelligibility and Acoustic Speech Performance of CAD/CAM Milled Titanium Partial Dentures · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07195201 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Ayse Tugba Erturk Avunduk
- Last refreshed: 26 September 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07195201.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing