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NCT07194772: NARELO
Sucralose and Glucose Metabolism in Young Healthy Adults
NA trial testing Low-calorie sweeteners (LCS) in Glucose Intolerance in 42 participants. Completed in 12 June 2024.
12 June 2024
Quick facts
| Lead sponsor | University of Ottawa |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 42 |
| Start date | 16 March 2022 |
| Primary completion | 12 June 2024 |
| Estimated completion | 12 June 2024 |
| Sites | 1 location across Canada |
Drugs / interventions tested
- Low-calorie sweeteners (LCS)
- Refined sugars (SSB)
- Natural sugars (FJ)
Conditions studied
- Glucose Intolerance — all drugs for Glucose Intolerance →
- Glucose and Insulin Response — all drugs for Glucose and Insulin Response →
- Glucose Homeostasis — all drugs for Glucose Homeostasis →
- Low-grade Inflammation — all drugs for Low-grade Inflammation →
Sponsor
University of Ottawa
Who can join
Adults 18 to 35, any sex, with Glucose Intolerance or Glucose and Insulin Response. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study aimed to investigate the effects of a three-week consumption of sucralose-sweetened beverages (low-calorie sweetener) on postprandial glycemic responses in healthy adults, compared with sugar-sweetened beverages under real-world conditions. In brief, postprandial glycemic responses are used as an indicator of how your body manages blood sugar levels after consuming glucose. To explore potential mechanisms underlying any observed changes in postprandial glycemic responses, we further investigated potential alterations in gut microbiota composition and functionality, as well as plasmatic biomarkers of intestinal permeability and systemic low-grade inflammation. Finally, this project explored whether free sugars derived from a natural source (100% natural fruit juice) elicit metabolic responses that differ from those of refined sugars. Participants visited the laboratory for a preliminary screening session to assess eligibility prior to being randomly assigned to one of the three experimental groups consuming either sucralose-sweetened beverages (LCS), sucrose-sweetened beverages (SSB), or 100% natural fruit juice (FJ) at dosage approximating real-world consumption over three weeks. Participants underwent two experimental sessions (duration of 3 hours each) at the beginning and completion of the study as outlined below.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT07194772
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07194772 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Ottawa
- Last refreshed: 26 September 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07194772.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing