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CaffeineHSC - Effect of Chronic Caffeine Consumption and Acute Caffeine Administration on the Hematopoietic System
This study investigates how caffeine intake affects blood stem and progenitor cells in healthy adults. The trial will compare people who regularly consume caffeine with those who consume very little or none. All participants will receive a single 200 mg caffeine tablet (similar to one cup of coffee) under fasting conditions. Blood samples will be collected before and three hours after caffeine intake. The study will assess whether caffeine influences the mobilization of blood stem and progenitor cells from the bone marrow into the bloodstream. It will also examine the effects of caffeine on the function, gene activity, and metabolism of blood cells.
Details
| Lead sponsor | Jasmin Rettkowski |
|---|---|
| Phase | NA |
| Status | NOT_YET_RECRUITING |
| Enrolment | 100 |
| Start date | 2025-10 |
| Completion | 2028-06 |
Conditions
- Healthy Adults; Hematopoietic System; Caffeine
Interventions
- Caffeine (200 mg)
Primary outcomes
- Mobilization of hematopoietic stem and progenitor cells — From baseline to three hours after caffeine intake
The change in the numbers of mobilized HSPCs (defined as CD34+ cells) \[cells/ml\] in blood (measured by flow cytometry) from baseline to three hours after intake of a single oral dose of 200mg caffeine in habitual caffeine consumers versus non-caffeine consumers. - Mobilization of hematopoietic stem and progenitor cells — From baseline to three hours after caffeine intake
The change in the relative abundance of HSPCs \[% HSPCs of total PBMCs\] in blood (measured by flow cytometry) from baseline to three hours after intake of a single oral dose of 200mg caffeine in habitual caffeine consumers versus non-caffeine consumers.
Countries
Switzerland