NCT07189585 (OA-INULIN) is a Phase 2 clinical trial of inulin in Knee Osteoarthritis, sponsored by Yale University.

Who is sponsoring NCT07189585?

NCT07189585 is sponsored by Yale University.

What drugs are being tested in NCT07189585?

Interventions in NCT07189585: inulin, Maltodextrin (Placebo).

What condition does NCT07189585 study?

NCT07189585 studies Knee Osteoarthritis.

Is NCT07189585 still recruiting?

NCT07189585 is currently not yet recruiting. Last updated 24 September 2025.

Last reviewed 2025-09-24 · How we verify

NCT07189585: OA-INULIN

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Inulin Supplementation for Reducing Inflammation and Knee Pain in Older Adults With Osteoarthritis

Not yet recruiting Phase 2 Last updated 24 September 2025

What this trial tests

Phase 2 trial testing inulin in Knee Osteoarthritis in 84 participants. Not yet recruiting.

Timeline

1 April 2026

Primary endpoint
31 July 2027

31 July 2027

Quick facts

Lead sponsor	Yale University
Phase	Phase 2
Status	Not yet recruiting
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	treatment
Enrollment	84
Start date	1 April 2026
Primary completion	31 July 2027
Estimated completion	31 July 2027
Sites	1 location across United States

Drugs / interventions tested

inulin — full drug profile →
Maltodextrin (Placebo) — full drug profile →

Conditions studied

Knee Osteoarthritis — all drugs for Knee Osteoarthritis →

Sponsor

Yale University

Who can join

40 and older, any sex, with Knee Osteoarthritis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study will test whether inulin, a type of dietary fiber, can reduce inflammation in older adults with knee osteoarthritis. Inflammation in the body may contribute to both joint pain and the progression of osteoarthritis. Inulin is a prebiotic fiber that may improve gut health and reduce lipopolysaccharide (LPS), a marker of bacterial products in the blood that is linked to inflammation. In this trial, participants with knee osteoarthritis will be randomly assigned to receive either inulin or a placebo (maltodextrin) for 8 weeks. The study will measure changes in blood LPS levels, knee pain, and other markers of inflammation. The goal is to determine whether inulin supplementation can improve pain and reduce inflammation in people with knee osteoarthritis.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

Verify or expand the search:

Other trials of inulin

Trials testing the same drug.

NCT07112248 — Effects of Soluble Fiber Supplements on Sperm Quality in Males With Obesity: a Randomized Trial · NA · not yet recruiting
NCT06551961 — Effect of Chronic Feeding of Inulin And Methylcellulose on Colonic Fermentation · NA · recruiting
NCT06420401 — Prebiotics and the Management of Hyperuricemia · NA · recruiting
NCT06404749 — Fungal Fiber for Gut Health · NA · terminated
NCT06551948 — Effect of MethylceIlulose or Psyllium on Fermentation of Inulin Assessed Using a Gas Sensing Capsule · NA · completed

Other recruiting trials for Knee Osteoarthritis

Currently open trials in the same condition.

NCT06906939 — A Randomized Pilot rTMS Trial for Knee Arthritis Pain and Depression · EARLY_PHASE1 · recruiting
NCT05823727 — Effects of Collagen Peptide Supplementation on Connective Tissue Remodeling, Functional Outcomes, and Wound Healing Afte · NA · recruiting
NCT07370480 — Knee Osteoarthritis and Thermal Spa Treatment · NA · recruiting
NCT07507175 — Gastrocnemius Myofascial Release in Females With Knee Osteoarthritis · NA · recruiting
NCT07386600 — Dexamethasone vs Dexmedetomidine for iPACK + ACB in TKA · NA · recruiting

Other Yale University trials

Trials by the same sponsor.

NCT06900998 — Pilot Study: Effects of Nimodipine on Alcohol Drinking · Phase 2 · not yet recruiting
NCT04910984 — Developing a Chatbot to Promote HIV Testing · NA · not yet recruiting
NCT07458087 — Accuracy of the Accuro 3S · NA · not yet recruiting
NCT07398404 — A Multiple Health Behavior Change (MHBC) Intervention for Weight Loss and Smoking Cessation for Pre-Bariatric Surgery Pa · Phase 1, PHASE2 · not yet recruiting
NCT07305324 — Improving Liver Fibrosis Diagnosis in Primary Care Using FibroX AI · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT07189585 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Yale University
Last refreshed: 24 September 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07189585.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing