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NCT07188987
Bilateral Sphenopalatine Ganglion Block Using Prilocaine Versus Lidocaine as Adjuvants to General Anesthesia During Endoscopic Hypophysectomy, Randomized Trial.
NA trial testing Sphenopalatine Ganglion Block using 2% lidocaine in Blood Pressure Control in 54 participants. Currently enrolling.
1 February 2026
Quick facts
| Lead sponsor | Kasr El Aini Hospital |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | prevention |
| Enrollment | 54 |
| Start date | 1 December 2025 |
| Primary completion | 1 February 2026 |
| Estimated completion | 1 February 2026 |
| Sites | 1 location across Egypt |
Drugs / interventions tested
- Sphenopalatine Ganglion Block using 2% lidocaine — full drug profile →
- Sphenopalatine Ganglion Block — full drug profile →
- Sphenopalatine Ganglion Block — full drug profile →
Conditions studied
- Blood Pressure Control — all drugs for Blood Pressure Control →
Sponsor
Kasr El Aini Hospital
Who can join
Adults 21 to 45, any sex, with Blood Pressure Control. Patients with the condition only — healthy volunteers not accepted.
What's being measured
Primary outcomes are the specific endpoints the trial is designed to prove or disprove.
-
MAP
Time frame: Mean arterial blood pressure in mmhg in the intraoperative period 5 minutes after nasal dissection
mean arterial blood pressure in the intraoperative period 5 minutes after nasal dissection -
MAP
Time frame: Mean arterial blood pressure in mmhg after 5 minutes of nasal dissection
mean arterial blood presssure 5 minutes after nasal dissection
Sponsor's own description
Patients undergoing endoscopic surgeries for pituitary adenoma excision suffer from wide swings in blood pressure that might increase bleeding and interfere with the surgical field. Local anethetic infiltration and regional nerve blocks have been used to provide better analgesia, control blood pressure and improve surgical field. Limited studies evaluated shenopalatine ganglion block in pituitary adenoma excision with promising outcomes. The proposed study will compare the efficacy of two local anesthetics, prilocaine and lidocaine, for spenopalatine ganglion block in patients undergoing endoscopic pituitary adenoma excision. Evaluating the control of the intraoperative blood pressure and analgesic sparing are the main objectives of the proposed study.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07188987
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Sphenopalatine Ganglion Block using 2% lidocaine
Trials testing the same drug.
- NCT06735261 — Sphenopalatine Block in Headache in Patients With Non-traumatic Subarachnoid Hemorrhage · NA · not yet recruiting
- NCT04401878 — SGB in Management of Patients With PDPH Using TCD · NA · completed
Other recruiting trials for Blood Pressure Control
Currently open trials in the same condition.
- NCT07208669 — Evaluating Whether Treating Elevated Blood Pressure in the Inpatient Setting Impacts Patient Outcomes · NA · recruiting
Other Kasr El Aini Hospital trials
Trials by the same sponsor.
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- NCT07274280 — Comparative Evaluation of Ambu AuraGain, LarySeal Pro and I-gel in Pediatric Airway Management for Day-Case Surgery Unde · NA · not yet recruiting
- NCT07348146 — Hand-Sewn vs. Stapled Anastomosis in SADI-S: Early Postoperative Complications. · NA · enrolling by invitation
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07188987 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Kasr El Aini Hospital
- Last refreshed: 30 November 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07188987.
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