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NCT07187635
Guiding Value of Urinary Tumor DNA Testing in Repeat Transurethral Resection of Non-Muscle-Invasive Bladder Cancer
NA trial testing Second Transurethral Resection of Bladder Tumor (re-TURBT) in Bladder Cancer in 196 participants. Currently enrolling.
1 October 2027
Quick facts
| Lead sponsor | Tianjin Medical University Second Hospital |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 196 |
| Start date | 28 September 2025 |
| Primary completion | 1 October 2027 |
| Estimated completion | 1 November 2027 |
| Sites | 2 locations across China |
Drugs / interventions tested
- Second Transurethral Resection of Bladder Tumor (re-TURBT)
- utDNA Testing (Urine Tumor DNA Detection)
Conditions studied
- Bladder Cancer — all drugs for Bladder Cancer →
- Liquid Biopsy — all drugs for Liquid Biopsy →
- Repeat Transurethral Resection of Bladder Tumor — all drugs for Repeat Transurethral Resection of Bladder Tumor →
Sponsor
Tianjin Medical University Second Hospital
Who can join
18 and older, any sex, with Bladder Cancer or Liquid Biopsy. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Non-muscle-invasive bladder cancer (NMIBC) accounts for approximately 75% of newly diagnosed bladder cancers and is characterized by a high risk of recurrence and progression. Current guidelines recommend that patients with stage T1 NMIBC undergo a second transurethral resection of bladder tumor (re-TURBT) within 2-6 weeks after the initial surgery to remove residual tumor, confirm staging, and obtain additional pathological information. However, the benefits of routine re-TURBT for all high-risk patients remain controversial, as many patients may not have residual disease, while the procedure carries surgical and anesthetic risks, physical and psychological burden, and additional healthcare costs. Urine tumor DNA (utDNA) refers to DNA fragments shed by tumor cells into urine. It can be detected using molecular assays with high sensitivity and specificity, offering a non-invasive method for bladder cancer diagnosis and surveillance. Previous studies have shown that positive utDNA results after initial TURBT may be associated with residual disease and higher recurrence risk. This multicenter, randomized controlled trial aims to evaluate whether utDNA testing can accurately identify NMIBC patients who are most likely to benefit from re-TURBT, thereby guiding the decision to perform the procedure. The goal is to optimize patient selection for re-TURBT, reduce unnecessary surgeries, and improve patient quality of life while maintaining oncologic safety.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
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Other Tianjin Medical University Second Hospital trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07187635 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Tianjin Medical University Second Hospital
- Last refreshed: 3 March 2026
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