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NCT07183969: LEST-CSchizo
The Effectiveness of Lower Extremity Strength Training
NA trial testing lower limb muscle strength training program in Patients With Chronic Schizophrenia in 78 participants. Completed in 26 January 2025.
16 January 2025
Quick facts
| Lead sponsor | National Taipei University of Nursing and Health Sciences |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | prevention |
| Enrollment | 78 |
| Start date | 20 September 2024 |
| Primary completion | 16 January 2025 |
| Estimated completion | 26 January 2025 |
| Sites | 1 location across Taiwan |
Drugs / interventions tested
- lower limb muscle strength training program
Conditions studied
- Patients With Chronic Schizophrenia — all drugs for Patients With Chronic Schizophrenia →
Sponsor
National Taipei University of Nursing and Health Sciences
Who can join
Adults 18 to 100, any sex, with Patients With Chronic Schizophrenia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The increase in chronic schizophrenia patients with sarcopenia is currently an important healthcare issue in Taiwan and requires enhanced prevention and progress. Therefore, the purpose of this study was to understand the prevalence of sarcopenia in patients with chronic schizophrenia and to explore the effect of lower limb strength training on the physical functional performance of patients with chronic schizophrenia and sarcopenia. This study adopted a quasi-experimental design method, and the research process was divided into two stages. In the first stage, the SARC-CalF questionnaire was used to initially screen suspected chronic schizophrenia patients in a psychiatric hospital in central Taiwan. For sarcopenia cases, the skeletal muscle mass index (Skeletal Muscle Mass index) of suspected sarcopenia cases is further compared with the body composition analyzer (Inboby) to confirm the diagnosis of sarcopenia. Statistical analysis of the prevalence of sarcopenia in patients with chronic schizophrenia. In the second phase of the study, 4 chronic disease areas (two chronic disease areas for men and women) were randomly divided into experimental groups and control groups. The experimental group received a 16-week lower limb muscle strength training program, while the control group received routine care. The two groups conducted one pre-test and two post-tests, and the measurement content included physical function performance (Short Physical Performance Battery (SPPB), sarcopenia quality of life (SarQoL), and fall incidence). It is expected that the development of a set of non-pharmacological care measures will help patients in chronic psychiatric wards to become independent and slow down the progression of sarcopenia.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07183969 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by National Taipei University of Nursing and Health Sciences
- Last refreshed: 19 September 2025
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