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NCT07180446
Can Gut Bacteria Predict Who Benefits Most From Exercise? A Gut Supplement to Help Exercise Non-Responders
NA trial testing Cardiovascular Exercise in Obesity &Amp; Overweight in 25 participants. Not yet recruiting.
10 August 2026
Quick facts
| Lead sponsor | Texas Christian University |
|---|---|
| Phase | NA |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 25 |
| Start date | 18 September 2025 |
| Primary completion | 10 August 2026 |
| Estimated completion | 10 August 2026 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Cardiovascular Exercise
- Butyrate — full drug profile →
Conditions studied
- Obesity &Amp; Overweight — all drugs for Obesity &Amp; Overweight →
Sponsor
Texas Christian University
Who can join
Adults 18 to 40, male only, with Obesity &Amp; Overweight. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this clinical trial is to learn how gut bacteria affect the way the body responds to exercise, especially how the body uses insulin. It also aims to learn if a supplement called sodium butyrate can help people who don't respond well to exercise alone. The main questions it aims to answer are: * Does exercise improve how the body uses insulin in male participants who have overweight or obesity? * Can gut bacteria predict who will benefit most from exercise? * Does sodium butyrate help improve insulin response in people who don't respond to exercise alone? Participants will: * Exercise 5 days a week for 12 weeks under supervision * Take sodium butyrate (a natural gut health supplement) daily for the last 4 weeks of the program * Provide blood and stool samples at three points during the study * Complete health and lifestyle questionnaires * Get body composition scans (DEXA) before, during, and after the study This study may help researchers find new ways to personalize exercise plans based on gut health and improve blood sugar control.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07180446
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
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Other Texas Christian University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07180446 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Texas Christian University
- Last refreshed: 18 September 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07180446.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing