NCT07180329

Zinc and Selenium Bioactivity

Completed NA Last updated 18 September 2025

What this trial tests

NA trial testing Myrin P Fort in Immunomodulatory Drugs in 90 participants. Completed in 25 July 2023.

Timeline

1 February 2023

Primary endpoint
25 July 2023

25 July 2023

Quick facts

Lead sponsor	University of Lahore
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	factorial
Masking	single
Primary purpose	supportive care
Enrollment	90
Start date	1 February 2023
Primary completion	25 July 2023
Estimated completion	25 July 2023
Sites	1 location across Pakistan

Drugs / interventions tested

• Myrin P Fort
• Zn + Se supplemented cookies
• Zn + Se + Myrin P Fort

Conditions studied

• Immunomodulatory Drugs — all drugs for Immunomodulatory Drugs →
• Tuberculosis — all drugs for Tuberculosis →

Sponsor

University of Lahore

Who can join

Adults 30 to 55, any sex, with Immunomodulatory Drugs or Tuberculosis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The primary hypothesis of the study was that zinc and selenium supplementation through fortified cookies would enhance the immune response and improve clinical outcomes in tuberculosis patients. For this purpose, a single-blind randomized control trial was carried out to determine the effect of zinc and selenium on the immunomodulatory parameters of tuberculosis approved by the Ethics Committee of the University of Lahore, Pakistan. In the first phase, the proximate and minerals profile of shiitake mushroom was analyzed, and functional cookies were developed fortified with zinc and selenium. In the second phase, 120 tuberculosis patients were divided into four groups (T0, T1, T2 \& T3) to assess the impact of supplementation on anthropometric, microbiological, and hematological parameters. Meanwhile, results were statistically examined through Principal component analysis and a heat map of the attributes under research were generated using R-studio (Version 4.2.2). However, results explained that the therapeutic effect of dosage on anthropometric, microbiological, and hematological measurements showed a significant result (p≤0.05), indicating that zinc and selenium may help to modulate the immunological response, and potentially improving the body's ability to resist tuberculosis.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Immunomodulatory Effects of Zinc and Selenium-Enriched <i>Lentinula edodes</i> Extract: Biochemical Characterization and Bioactivity Relevant to Tuberculosis.
   Mughal H, Tufail T, Ain HBU, Rasheed A, et al · · 2026 · PMID 41971609 · DOI 10.1002/fsn3.71736