Last reviewed · How we verify
NCT07180043
Propranolol for Pediatric Migraine: A Prospective Clinical Study
NA trial testing Structured Behavioral Therapy in Pediatric Migraine in 178 participants. Completed in 30 December 2023.
1 January 2023
Quick facts
| Lead sponsor | Kayseri University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 178 |
| Start date | 1 January 2021 |
| Primary completion | 1 January 2023 |
| Estimated completion | 30 December 2023 |
| Sites | 1 location across Turkey (Türkiye) |
Drugs / interventions tested
- Structured Behavioral Therapy
- Propranolol (propranolol) — full drug profile →
Conditions studied
- Pediatric Migraine — all drugs for Pediatric Migraine →
- Headache Disorders — all drugs for Headache Disorders →
Sponsor
Kayseri University
Who can join
Adults 6 to 16, any sex, with Pediatric Migraine or Headache Disorders. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This prospective, controlled clinical trial was conducted to evaluate the effectiveness of propranolol compared with structured behavioral therapy in pediatric patients diagnosed with primary migraine according to ICHD-3 criteria. A total of 178 children aged 6 to 16 years were enrolled between January 2021 and December 2023 at a tertiary pediatric neurology center. Participants were allocated into two groups based on baseline Pediatric Migraine Disability Assessment (PedMIDAS) scores: Group 1 received standardized behavioral therapy, while Group 2 received propranolol at doses ranging from 1-3 mg/kg/day for 12 weeks. Primary outcomes included changes in PedMIDAS and Visual Analog Scale (VAS) scores. Secondary analyses investigated clinical and biochemical predictors of propranolol responsiveness, including benign paroxysmal vertigo, essential tremor, anxiety, vitamin D status, and vitamin B12 levels. The study aims to provide evidence for a more personalized approach to migraine prophylaxis in children by integrating clinical, psychiatric, and nutritional predictors of treatment response.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Clinical predictors of propranolol responsiveness in pediatric migraine: a prospective observational study.
Baykan M, Didinmez Taşkırdı E, Baykan Çopuroğlu Ö, Gençpınar P, et al · · 2026 · PMID 41914064 · DOI 10.22514/jofph.2026.026
Verify or expand the search:
- PubMed search for NCT07180043
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Pediatric Migraine
Currently open trials in the same condition.
- NCT07419607 — MIGRAFIT: Evaluating a Group Therapy Program Combining Physical Activity, Progressive Muscle Relaxation and Psychoeducat · NA · recruiting
- NCT07092241 — The Efficacy of Beneficial Intestinal Microbiota in the Treatment of Migraine and Its Mechanism: Basic and Clinical Stud · NA · active not recruiting
- NCT04649242 — Randomized Study in Children and Adolescents With Migraine: Acute Treatment · Phase 3 · recruiting
Other Kayseri University trials
Trials by the same sponsor.
- NCT06635343 — The Effect of Inspiratory Muscle Training on Respiratory Function, Balance and Functional Capacity in Trainable Mentally · NA · completed
- NCT07103031 — Comorbidity-Based Propranolol Use in Pediatric Migraine · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07180043 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Kayseri University
- Last refreshed: 18 September 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07180043.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing