Changes in Muscle Mass, Strength, and Muscle Protein Synthesis in Response to 5 Days of Bedrest in Young, Healthy Adults (FABRIC)

NCT07178353 NA RECRUITING

The goal of this intervention trial is to characterize skeletal muscle atrophy in healthy, young adults during short term bedrest. The main questions it aims to answer are: How much do skeletal muscle volume, strength, and fatigue resistance decline during bedrest? How much does whole-body insulin sensitivity change during bedrest? How do mitochondrial function and protein synthesis change during bedrest? Participants will undergo the following tests before and after a free-living control period and before and after a 5 day period of strict horizontal bedrest: * Magnetic resonance imaging of the thigh muscles * Strength testing of the thigh muscles * Insulin sensitivity testing in response to a mixed meal * Exogenous glucose oxidation in response to a mixed meal * Muscle biopsies from the thigh muscles * Blood samples

Details

Lead sponsor	Queen's University
Phase	NA
Status	RECRUITING
Enrolment	12
Start date	2025-09
Completion	2027-06

Conditions

• Muscular Atrophy
• Insulin Resistance
• Muscle Protein Synthesis

Interventions

• Bedrest

Primary outcomes

• Quadriceps muscle volume — Day 0, and 5
  Quadriceps muscle volume will be assessed by magnetic resonance imaging.

Countries

Canada