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NCT07177898
ALLOPURINOL AND LISINOPRIL FOR DIABETIC KIDNEY PROTECTION: A COMPARATIVE STUDY IN NORMOURICEMIC TYPE 2 DIABETICS
NA trial testing Allopurinol in Diabetic Kidney Disease (DKD) in 80 participants. Completed in 18 November 2024.
23 September 2024
Quick facts
| Lead sponsor | Narowal Medical College |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 80 |
| Start date | 14 May 2023 |
| Primary completion | 23 September 2024 |
| Estimated completion | 18 November 2024 |
| Sites | 1 location across Pakistan |
Drugs / interventions tested
- Allopurinol (ALLOPURINOL) — full drug profile →
Conditions studied
- Diabetic Kidney Disease (DKD) — all drugs for Diabetic Kidney Disease (DKD) →
Sponsor
Narowal Medical College
Who can join
35 and older, any sex, with Diabetic Kidney Disease (DKD). Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This randomized controlled trial was conducted at the Department of Medicine and Diabetes of Mayo Hospital/King Edward Medical University, Lahore, over one year. A total of 80 patients with type 2 diabetes and normal serum uric acid were randomly assigned to two groups: Group A received allopurinol with lisinopril, and Group B received lisinopril alone. Patients were monitored every three months for serum creatinine, spot urine albumin, and serum uric acid levels. The primary endpoint was a \>300 mg/L increase in urine albumin from baseline. Blood pressure was managed with agents other than ACE inhibitors if required.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT07177898
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
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- Google Scholar
Related trials
Other trials of Allopurinol
Trials testing the same drug.
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- NCT07089875 — A Study of Dotinurad Versus Allopurinol in Participants With Gout · Phase 3 · recruiting
- NCT05888233 — Allopurinol Improves Heart Function in African Americans With Resistant Hypertension · Phase 2 · recruiting
- NCT06276556 — Extension Study of ABP-671 in Participants With Gout · Phase 2, PHASE3 · terminated
- NCT04875702 — Treat-to-Target Serum Urate Versus Treat-to-Avoid Symptoms in Gout · Phase 4 · recruiting
Other recruiting trials for Diabetic Kidney Disease (DKD)
Currently open trials in the same condition.
- NCT07271186 — Study to Assess the Effects of Angiopoietin-like Protein 3 (ANGPTL3) Inhibition in Adult Participants With Diabetic Kidn · Phase 2 · recruiting
- NCT07348718 — Rubix LS Diabetic Kidney Disease (DKD) Registry Study · active not recruiting
- NCT06969807 — Safety and Efficacy of Mesenchymal Stromal Cells (Amimestrocel ) in Diabetic Kidney Disease · Phase 2 · recruiting
- NCT06962098 — Efficacy and Safety Study of Isuzinaxib in Subjects With DKD · Phase 2 · recruiting
- NCT06866158 — Autologous Dendritic Cell as Adjunct Therapy for Diabetic Kidney Disease · Phase 1, PHASE2 · active not recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07177898 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Narowal Medical College
- Last refreshed: 17 September 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07177898.
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