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Methylprednisolone vs Dexamethasone Interaction With Sugammadex in Pediatric Patients
This randomized controlled trial aims to compare the interaction of methylprednisolone and dexamethasone with sugammadex in pediatric patients undergoing adenoidectomy and/or tonsillectomy. The primary objective is to evaluate the effect of these corticosteroids on the reversal time of rocuronium-induced neuromuscular block by sugammadex. Secondary outcomes include postoperative pain, nausea and vomiting, extubation time, and adverse events. Eligible participants are children aged 5 to 12 years, ASA I-II, scheduled for elective surgery under general anesthesia. The study is designed as a triple-blind, parallel-group trial with three arms: methylprednisolone, dexamethasone, and placebo.
Details
| Lead sponsor | Konya City Hospital |
|---|---|
| Phase | NA |
| Status | COMPLETED |
| Enrolment | 60 |
| Start date | Tue Sep 16 2025 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Sat Dec 20 2025 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- Neuromuscular Block, Residual
- Pain Management
- Postoperative Nausea
Interventions
- Methyl Prednisolone (MP)
- Dexamethasone (0.2 mg/kg)
- Saline (0.9% NaCl)
Countries
Turkey (Türkiye)