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NCT07173738
Pharmacokinetics, Safety and Tolerability of Concurrent Doses of BIA 5-1058 and Furosemide
Phase 1 trial testing BIA 5-1058 in Pulmonary Arterial Hypertension in 44 participants. Completed in 7 September 2018.
7 September 2018
Quick facts
| Lead sponsor | Bial - Portela C S.A. |
|---|---|
| Phase | Phase 1 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | sequential |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 44 |
| Start date | 11 June 2018 |
| Primary completion | 7 September 2018 |
| Estimated completion | 7 September 2018 |
| Sites | 1 location across United Kingdom |
Drugs / interventions tested
- BIA 5-1058 — full drug profile →
- Furosemide (furosemide) — full drug profile →
- BIA 5-1058 and Furosemide — full drug profile →
Conditions studied
- Pulmonary Arterial Hypertension — all drugs for Pulmonary Arterial Hypertension →
Sponsor
Bial - Portela C S.A. — full company profile →
Who can join
Adults 18 to 55, any sex, with Pulmonary Arterial Hypertension. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The purpose of this study is: * To assess the effect of BIA 5 1058 400 mg on furosemide pharmacokinetics (PK). * To assess the effect of furosemide 40 mg on the PK of BIA 5 1058.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT07173738
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of BIA 5-1058
Trials testing the same drug.
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- NCT03489005 — Effect of BIA 5 1058 on Cardiac Repolarization · Phase 1 · completed
- NCT04994860 — Effect of BIA 5-1058 400 mg on the Steady State Pharmacokinetics of Sildenafil · Phase 1 · completed
- NCT04675944 — Effect of BIA 5-1058 on the Steady State Pharmacokinetics of Treprostinil · Phase 1 · completed
- NCT04994119 — Effect of BIA 5-1058 400 mg on Warfarin Pharmacokinetics · Phase 1 · completed
Other recruiting trials for Pulmonary Arterial Hypertension
Currently open trials in the same condition.
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- NCT07217522 — Rutgers University Study of the Genetics of Pulmonary Hypertension · recruiting
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- NCT06658522 — Right Ventricular Compensation With Sotatercept: A Prospective Single Arm Open Label Phase 4 Study to Evaluate the Effec · Phase 4 · recruiting
Other Bial - Portela C S.A. trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07173738 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Bial - Portela C S.A.
- Last refreshed: 15 September 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07173738.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing