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NCT07172308
High Risk Atherosclerosis Identified at Cardiac CT Among Patients With vs Without Family History of CAD
trial in Coronary Artery Disease (CAD) in 480 participants. Completed in 1 August 2025.
15 May 2025
Quick facts
| Lead sponsor | I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 480 |
| Start date | 15 January 2025 |
| Primary completion | 15 May 2025 |
| Estimated completion | 1 August 2025 |
| Sites | 1 location across Italy |
Conditions studied
- Coronary Artery Disease (CAD) — all drugs for Coronary Artery Disease (CAD) →
- Atherosclerosis of Coronary Artery — all drugs for Atherosclerosis of Coronary Artery →
Sponsor
I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio — full company profile →
Who can join
Adults 40 to 70, any sex, with Coronary Artery Disease (CAD) or Atherosclerosis of Coronary Artery. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Acute coronary syndrome often represtent the first drammatic manifestation of coronary atherosclerosis. Cardiac computed tomography angiography (CCTA) has recently gained a pivotal role in the evalution of patients with suspected coronary artery disease (CAD). Of inteterst, it may provide important information on coronary atherosclerosis beyond lumen stenosis; more precisely high risk plaque features could be identified even in the abesence of significative lumen stenosis (i.e. not flow-limiting lesions). The evidence of non-obstructive but high risk atheroscleorisis may support aggressive primary prevention treatment, reducing the risk of future cardiovascular events. Even if familty history of CAD is considered a risk factor for cardiovascular events, no clear data are available regarding the prevalence of coronary atherosclerosis in this subgroup of patients and CCTA in asymptomatic subjects is not clearly supported by evidence nor suggested by guidelines. Aim of our study is to explore whether the prevalence of high risk coronary atherosclerosis among patients with family hystory of CAD is different when compared with a group of patients without family hystory of CAD. For that purpose from consecutive registry of patient who underwent clinically indicated CCTA for suspected but unknown CAD a cohort of patients with family history of CAD as first early presentation of coronary atherosclerosis (group 1) will be compared with a consecutive cohort of subjects without familiy history of CAD (group 2). All CCTA will be perfomed according to most recent guidelines and advanced atheroscleoris analysis will be performed. As primary objective of the study, the prevalence of high risk atherosclerosis will be compared between the two Groups. The evidence of higher prevalence of high-risk atherosclerosis prevalence in group 1 vs group 2 may further support the use of CCTA in asymptomatic patients but with family history of CAD.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT07172308
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07172308 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
- Last refreshed: 15 September 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07172308.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing