Who is sponsoring NCT07171762?

NCT07171762 is sponsored by KEZBAN MELTEM ÇOLAK.

What condition does NCT07171762 study?

NCT07171762 studies Apical Periodontitis, Oxidative Stress.

What drugs are being tested in NCT07171762?

Interventions: Ozonytron XP, Physiological saline solution (0.9% NaCl).

What is the status of NCT07171762?

NCT07171762 is currently ACTIVE_NOT_RECRUITING.

Last reviewed 2025-09-18 · How we verify

Effect of Ozone Use in Intracanal Irrigation on Oxidative Stress Level in Teeth With Asymptomatic Apical Periodontitis

NCT07171762 NA ACTIVE_NOT_RECRUITING

This clinical study aims to investigate the oxidative stress-related effects of ozone irrigation in patients with asymptomatic apical periodontitis undergoing root canal treatment. A total of 60 patients who meet the inclusion criteria will be randomly assigned into two groups using an online randomization tool: an ozone irrigation group and a saline irrigation (control) group. The primary objective is to assess the biochemical effects of ozone therapy on oxidative stress markers in periapical interstitial fluid, including but not limited to TAS, TOS, MDA, and 8-OHdG, by using ELISA kits. After routine canal preparation and initial irrigation protocol (NaOCl-EDTA-NaOCl), baseline periapical fluid samples will be collected using standardized sterile paper points. Following this, experimental irrigation will be applied: ozone water in the study group and saline solution in the control group. Second periapical fluid samples will be collected immediately after this procedure. Subsequently, calcium hydroxide dressing will be placed into the canals, and the patients will be recalled after one week. At the second visit, after removal of the intracanal medicament, a third sample will be collected from each patient. Ethical approval was obtained from the Non-Interventional Clinical Research Ethics Committee of Atatürk University Faculty of Medicine. The results of this study are expected to contribute to the understanding of ozone therapy as a biocompatible and effective disinfection agent in endodontic procedures and to provide insights into its role in modulating oxidative stress within the periapical environment.

Details

Lead sponsor	KEZBAN MELTEM ÇOLAK
Phase	NA
Status	ACTIVE_NOT_RECRUITING
Enrolment	60
Start date	Fri Sep 27 2024 00:00:00 GMT+0000 (Coordinated Universal Time)
Completion	Thu Oct 30 2025 00:00:00 GMT+0000 (Coordinated Universal Time)

Conditions

Apical Periodontitis
Oxidative Stress

Interventions

Ozonytron XP
Physiological saline solution (0.9% NaCl)

Countries

Turkey (Türkiye)