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NCT07171112
Smoking Cessation Trial in Recurrent Acute Pancreatitis and Chronic Pancreatitis
Phase 2 trial testing Standard Varenicline Dosing (1 mg BID) in Pancreatitis, Chronic in 45 participants. Currently enrolling.
1 October 2027
Quick facts
| Lead sponsor | Mayo Clinic |
|---|---|
| Phase | Phase 2 |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | sequential |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 45 |
| Start date | 6 November 2025 |
| Primary completion | 1 October 2027 |
| Estimated completion | 1 October 2028 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Standard Varenicline Dosing (1 mg BID) — full drug profile →
- Bupropion 150 mg twice daily — full drug profile →
- Increased Varenicline Dosing (1mg TID) — full drug profile →
Conditions studied
- Pancreatitis, Chronic — all drugs for Pancreatitis, Chronic →
- Pancreatitis, Acute — all drugs for Pancreatitis, Acute →
- Recurrent Acute Pancreatitis — all drugs for Recurrent Acute Pancreatitis →
- Smoking (Tobacco) Addiction — all drugs for Smoking (Tobacco) Addiction →
Sponsor
Mayo Clinic
Who can join
18 and older, any sex, with Pancreatitis, Chronic or Pancreatitis, Acute. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The purpose of this research is to assess the effectiveness of two treatment strategies for smoking cessation in patients with acute recurrent pancreatitis or chronic pancreatitis who smoke cigarettes. All participants will receive varenicline, a commonly used medication that helps people stop smoking, at its standard dose. For those who are unable to stop smoking after 6 weeks of treatment, they will be randomly selected to either 1) increase their dose of varenicline, 2) combine varenicline with bupropion (another medication that helps with smoking cessation) or continue on the standard dose of varenicline. At the end of 12 weeks of treatment, participants will be asked if they have stopped smoking with confirmation done by measuring carbon monoxide levels in their breath.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07171112
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07171112 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Mayo Clinic
- Last refreshed: 10 November 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07171112.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing