NCT07158216 (RECONNECT-PLUS) is a NA clinical trial of TMS in Primary Progressive Aphasia(PPA), sponsored by Hospital San Carlos, Madrid.

Who is sponsoring NCT07158216?

NCT07158216 is sponsored by Hospital San Carlos, Madrid.

What drugs are being tested in NCT07158216?

Interventions in NCT07158216: TMS, tDCS, Sham TMS, Sham tDCS.

What condition does NCT07158216 study?

NCT07158216 studies Primary Progressive Aphasia(PPA).

Is NCT07158216 still recruiting?

NCT07158216 is currently recruiting now. Last updated 19 April 2026.

Last reviewed 2026-04-19 · How we verify

NCT07158216: RECONNECT-PLUS

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Long-term Effect of Transcranial Magnetic Stimulation and Transcranial Electrical Stimulation in Primary Progressive Aphasia: Randomized, Double-blind Clinical Trial (RECONNECT-PLUS)

Recruiting now NA Last updated 19 April 2026

What this trial tests

NA trial testing TMS in Primary Progressive Aphasia(PPA) in 80 participants. Currently enrolling.

Timeline

15 September 2025

Primary endpoint
1 December 2028

1 December 2028

Quick facts

Lead sponsor	Hospital San Carlos, Madrid
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	treatment
Enrollment	80
Start date	15 September 2025
Primary completion	1 December 2028
Estimated completion	1 December 2028
Sites	1 location across Spain

Drugs / interventions tested

TMS — full drug profile →
tDCS — full drug profile →
Sham TMS
Sham tDCS

Conditions studied

Primary Progressive Aphasia(PPA) — all drugs for Primary Progressive Aphasia(PPA) →

Sponsor

Hospital San Carlos, Madrid

Who can join

18 and older, any sex, with Primary Progressive Aphasia(PPA). Patients with the condition only — healthy volunteers not accepted.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

Mini-Linguistic State Examination
Time frame: 6 months

Sponsor's own description

The goal of this clinical trial is to investigate the effect of non-invasive brain stimulation techniques in the progression of primary progressive aphasia for 6 months. We will compare three modalities of brain stimulation (TMS, tDCS, TMS+tDCS) against sham stimulation. All patients will receive also language therapy.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Long-term effect of transcranial magnetic stimulation and transcranial electrical stimulation in primary progressive aphasia: study protocol for a randomised, double-blind clinical trial (RECONNECT-PLUS).
Fernández-Romero L, Díez-Cirarda M, Delgado-Alonso C, Cabrera-Martin MN, et al · · 2026 · PMID 42161537 · DOI 10.1136/bmjopen-2025-112999

Verify or expand the search:

Other trials of TMS

Trials testing the same drug.

NCT07346794 — The Underlying Neural Mechanism of TMS in Improving the Imbalance of "Microbiota-brain-gut Axis" in Alzheimer 's Disease · NA · not yet recruiting
NCT07290738 — Transcranial Magnetic Stimulation (TMS) for Negative Symptoms in Schizophrenia Spectrum Disorders · NA · recruiting
NCT07010614 — Brain Stimulation to the Hippocampus in Schizophrenia · NA · recruiting
NCT06274112 — Using TMS to Understand Neural Processes of Social Motivation · NA · recruiting
NCT07147218 — Accelerated TMS for MDD · NA · recruiting

Other recruiting trials for Primary Progressive Aphasia(PPA)

Currently open trials in the same condition.

NCT06739967 — Speech and Language Interventions for Italian People With PPA · recruiting
NCT04715399 — UPenn Observational Research Repository on Neurodegenerative Disease · recruiting

Other Hospital San Carlos, Madrid trials

Trials by the same sponsor.

NCT06310941 — Mechanical Insufflation-exsufflation and Hypertonic Saline in Nosocomial Bacterial Respiratory Tract Infection · NA · not yet recruiting
NCT07002658 — Clinical Impact of Surgical Wound Morbidity According to the Type of Saphenous Vein Harvesting Technique (Endoscopic vs. · NA · not yet recruiting
NCT06113939 — Prevention of Infection of the Respiratory Tract Through Application of Non-Invasive Methods of Secretion Suctioning · NA · not yet recruiting
NCT06156059 — Oral Bedtime Melatonin in Critically Ill Patients · Phase 4 · unknown
NCT07390175 — Ablation of Human Cardiac Fibrillation Based on Models of Hierarchical Organization of Tissue Excitation · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT07158216 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Hospital San Carlos, Madrid
Last refreshed: 19 April 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07158216.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing