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NCT07157332: IRON-XL
Iron Metabolism in Obesity
trial testing Bariatric Sleeve Surgery in Obesity (Disorder) in 50 participants. Not yet recruiting.
15 November 2025
Quick facts
| Lead sponsor | TecSalud Investigación Clínica |
|---|---|
| Status | Not yet recruiting |
| Study type | OBSERVATIONAL |
| Enrollment | 50 |
| Start date | 15 September 2025 |
| Primary completion | 15 November 2025 |
| Estimated completion | 15 August 2027 |
| Sites | 1 location across Mexico |
Drugs / interventions tested
- Bariatric Sleeve Surgery
Conditions studied
- Obesity (Disorder) — all drugs for Obesity (Disorder) →
Sponsor
TecSalud Investigación Clínica — full company profile →
Who can join
Adults 18 to 50, any sex, with Obesity (Disorder). Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study consists of two phases and aims to understand how obesity and systemic iron deficiency affect iron accumulation in important organs such as the liver and heart, as well as oxidative stress in fat tissue cells. In Phase 1, researchers will compare individuals with obesity who have iron deficiency to those without, to see if there are differences in the amount of iron stored in the liver and heart, measured by magnetic resonance imaging (MRI), and in oxidative stress and labile iron in visceral and subcutaneous fat tissue, assessed through biopsies. Phase 2 is a six-month prospective cohort study following the same individuals after they undergo bariatric surgery, a weight-loss surgery. The goal is to evaluate whether weight and fat loss normalize iron accumulation in the liver and heart, reduce oxidative stress, improve systemic iron metabolism, enhance blood sugar control, support liver function, modulate chronic inflammation, and restore gut microbiota diversity. Researchers will compare these health changes between individuals with and without iron deficiency. The study includes adults aged 18 to 50 with obesity living in the metropolitan area of Monterrey, Mexico, who are scheduled for laparoscopic sleeve gastrectomy surgery and agree to participate. The findings could improve understanding of how iron metabolism interacts with obesity-related complications and may lead to better treatments and management strategies for people with obesity and iron deficiency.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07157332
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Other TecSalud Investigación Clínica trials
Trials by the same sponsor.
- NCT07455630 — Cardiac Function and Biomarkers in Patients With Obesity and Overweight · completed
- NCT04514302 — Safety and Efficacy of Anti-SARS-CoV-2 Equine Antibody F(ab')2 Fragments (INOSARS) for Adult Patients With Mild COVID-19 · Phase 1 · completed
- NCT04333355 — Safety in Convalescent Plasma Transfusion to COVID-19 · Phase 1 · terminated
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07157332 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by TecSalud Investigación Clínica
- Last refreshed: 5 September 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07157332.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing