Last reviewed · How we verify
NCT07154043
Comparison of IPC Therapy as an Alternative or an Adjunct to MLD Within CDT for BCRL
NA trial testing Complete Decongestive Therapy (CDT) in Breast Cancer-Related Lymphedema in 45 participants. Currently enrolling.
1 December 2026
Quick facts
| Lead sponsor | Pamukkale University |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 45 |
| Start date | 15 September 2025 |
| Primary completion | 1 December 2026 |
| Estimated completion | 1 December 2026 |
| Sites | 1 location across Turkey (Türkiye) |
Drugs / interventions tested
- Complete Decongestive Therapy (CDT)
- CDT + Intermittent Pneumatic Compression (IPC)
- CDT without Manual Lymph Drainage plus Intermittent Pneumatic Compression
Conditions studied
- Breast Cancer-Related Lymphedema — all drugs for Breast Cancer-Related Lymphedema →
- BCRL — all drugs for BCRL →
Sponsor
Pamukkale University
Who can join
Adults 18 to 65, female only, with Breast Cancer-Related Lymphedema or BCRL. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Breast cancer is the most common cancer among women worldwide and lymphedema is one of its most significant complications. Breast cancer-related lymphedema (BCRL) may develop shortly after treatment or even years later, causing physical and psychological burden, functional impairment, and reduced quality of life. Complete decongestive therapy (CDT), which includes manual lymph drainage (MLD), compression, skin care, and exercise, is the standard approach. Intermittent pneumatic compression (IPC) has been proposed as an additional option, and current consensus reports emphasize the need for studies evaluating IPC in combination with MLD. Previous studies comparing IPC and MLD, either alone or in combination, have shown inconsistent results. Some reported no significant difference between treatment groups, while others suggested additional benefits of IPC, particularly in reducing limb heaviness and tension. However, there is still insufficient evidence to clarify the exact role of IPC within CDT. The aim of this study is to investigate the acute effects of using IPC instead of MLD, or in combination with MLD, on arm circumference, arm volume, shoulder range of motion, and quality of life in patients with BCRL.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07154043
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Complete Decongestive Therapy (CDT)
Trials testing the same drug.
- NCT03762044 — New Therapeutic Approach in Upper Limb Lymphedema Secondary to Breast Cancer: Activity-oriented Proprioceptive Antiedema · NA · completed
Other Pamukkale University trials
Trials by the same sponsor.
- NCT06667856 — Foot Core Exercise Training With Telerehabilitation · NA · suspended
- NCT07532499 — EMG-Triggered Electrical Stimulation After Median/Ulnar Nerve Repairs · NA · not yet recruiting
- NCT07473232 — Comparison of Platelet-rich Plasma and Activated Cytokine-rich Serum Injection Treatments in Patients With Knee Osteoart · NA · not yet recruiting
- NCT07520084 — Predictors of Climate Change Health Literacy in Older Individuals · recruiting
- NCT07388316 — Functional Improvement and Fine Dexterity in Thumb Tendon Injuries · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07154043 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Pamukkale University
- Last refreshed: 4 March 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07154043.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing