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NCT07152834: AATD-SAO
Screening for Alpha-1 Antitrypsin Deficiency in Patients With Airway Obstruction
trial testing Blood Sampling in Alpha 1-antitrypsin Deficiency (AATD) in 734 participants. Currently enrolling.
30 December 2025
Quick facts
| Lead sponsor | Muğla Sıtkı Koçman University |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 734 |
| Start date | 6 August 2025 |
| Primary completion | 30 December 2025 |
| Estimated completion | 5 January 2026 |
| Sites | 1 location across Turkey (Türkiye) |
Drugs / interventions tested
- Blood Sampling — full drug profile →
Conditions studied
- Alpha 1-antitrypsin Deficiency (AATD) — all drugs for Alpha 1-antitrypsin Deficiency (AATD) →
Sponsor
Muğla Sıtkı Koçman University
Who can join
18 and older, any sex, with Alpha 1-antitrypsin Deficiency (AATD). Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Brief Summary: This study aims to find out if a genetic condition called Alpha-1 Antitrypsin Deficiency (AATD) is more common in people who have shortness of breath and signs of airway obstruction on their breathing tests. Alpha-1 antitrypsin (AAT) is a protein that protects the lungs from damage. AATD is an inherited condition where the body does not make enough of this protein, which can lead to lung diseases like emphysema, especially in smokers. Investigators hypothesize that low AAT levels or related genetic mutations may be a contributing factor to airway obstruction in patients complaining of shortness of breath. To test this, investigators will recruit patients from our outpatient clinic who are being evaluated for shortness of breath and are having a standard breathing test (spirometry). Investigators will measure their AAT levels and test for the most common genetic mutations that cause AATD using a small blood sample. Investigators will then compare the AAT levels and genetic results between different groups of patients, such as smokers and non-smokers with and without airway obstruction. Investigators will also see if the severity of a patient's shortness of breath is related to their AAT levels. The goal is to improve the detection of AATD in this patient population, which could lead to better diagnoses and specific treatments for those who have this condition.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07152834
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07152834 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Muğla Sıtkı Koçman University
- Last refreshed: 10 September 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07152834.
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