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NCT07144878
Parasternal Intercostal Ultrasound vs RSBI for Weaning Prediction
NA trial testing Parasternal Intercostal Ultrasound and RSBI Assessment in Respiratory Insufficiency in 50 participants. Completed in 25 June 2024.
1 April 2024
Quick facts
| Lead sponsor | Benha University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | diagnostic |
| Enrollment | 50 |
| Start date | 3 October 2023 |
| Primary completion | 1 April 2024 |
| Estimated completion | 25 June 2024 |
| Sites | 1 location across Egypt |
Drugs / interventions tested
- Parasternal Intercostal Ultrasound and RSBI Assessment
Conditions studied
- Respiratory Insufficiency — all drugs for Respiratory Insufficiency →
- Weaning, Ventilator — all drugs for Weaning, Ventilator →
- Respiration, Artificial — all drugs for Respiration, Artificial →
- Intensive Care Units — all drugs for Intensive Care Units →
Sponsor
Benha University
Who can join
Adults 18 to 80, any sex, with Respiratory Insufficiency or Weaning, Ventilator. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Mechanical ventilation is essential in the management of critically ill patients, but deciding the proper time to wean and extubate remains a significant challenge. Extubation failure is associated with poor outcomes, including prolonged intensive care unit stay, higher risk of complications, and increased mortality. The rapid shallow breathing index (RSBI) is widely used to predict weaning readiness, but its predictive accuracy is limited. Recently, ultrasound evaluation of respiratory muscles, particularly the parasternal intercostal muscle, has been proposed as a promising bedside tool to assess respiratory effort and load. This comparative clinical trial was conducted on adult intensive care unit patients at Benha University Hospital who were mechanically ventilated for ≤24 hours and ready for a spontaneous breathing trial. Each patient underwent both rapid shallow breathing index (RSBI) measurement and parasternal intercostal muscle ultrasound prior to the trial. Patients were classified into successful or failed weaning groups based on trial outcome. The study compared the diagnostic accuracy of both methods and aimed to determine whether ultrasound assessment of the parasternal intercostal muscle offers a more reliable predictor of weaning success than rapid shallow breathing index (RSBI).
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT07144878
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07144878 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Benha University
- Last refreshed: 28 August 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07144878.
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