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Effects of a Probiotic Intervention on the Gut and Vaginal Microbiome in Patients With Advanced or Recurrent Ovarian Cancer Undergoing Treatment With Platinum Chemotherapy
This clinical trial evaluates the effects a probiotic intervention has on the gut and vaginal microbiome in patients undergoing chemotherapy for ovarian cancer that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced) or that has come back after a period of improvement (recurrent). Gut health is also known as the gut microbiome. The microbiome includes all of the bacteria and organisms naturally found in the digestive tract. Probiotics are dietary supplements containing live microorganisms that may help keep the gastrointestinal tract healthy. A probiotic intervention during platinum chemotherapy in ovarian cancer patients may impact the gut and vaginal microbiota, quality of life, symptoms, and oncologic outcomes.
Details
| Lead sponsor | Ohio State University Comprehensive Cancer Center |
|---|---|
| Phase | EARLY_PHASE1 |
| Status | RECRUITING |
| Enrolment | 161 |
| Start date | Mon Mar 09 2026 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Fri Jul 09 2027 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- Advanced Ovarian Carcinoma
- Recurrent Ovarian Carcinoma
- Stage II Ovarian Cancer AJCC v8
- Stage III Ovarian Cancer AJCC v8
- Stage IV Ovarian Cancer AJCC v8
Interventions
- Biospecimen Collection
- Placebo Administration
- Probiotic
- Questionnaire Administration
Countries
United States