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NCT07143370
Microbial Colonization in Three Dimensional (3D) Printed Orthodontic Clear Aligners
NA trial testing Thermoformed clear aligner in Orthodontic Aligner in 30 participants. Completed in 17 October 2025.
17 October 2025
Quick facts
| Lead sponsor | University of Michigan |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | single |
| Primary purpose | supportive care |
| Enrollment | 30 |
| Start date | 2 September 2025 |
| Primary completion | 17 October 2025 |
| Estimated completion | 17 October 2025 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Thermoformed clear aligner
- 3D printed clear aligner TC-85
- 3D printed clear aligner TA-28
Conditions studied
- Orthodontic Aligner — all drugs for Orthodontic Aligner →
- Microbial Colonization — all drugs for Microbial Colonization →
Sponsor
University of Michigan
Who can join
18 and older, any sex, with Orthodontic Aligner or Microbial Colonization. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study is being done to compare conventional clear aligners with 3D printed clear aligners to assess if there is any significant difference between the microbial colonization of these appliances. The 3D printed aligner material and conventional aligner materials are being used for investigational purposes and have been approved for their use in fabricating clear aligners for orthodontic tooth movement, but not for the purposes of our study, which is for the fabrication of clear passive aligners to assess microbial colonization.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT07143370
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07143370 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Michigan
- Last refreshed: 6 November 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07143370.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing