Last reviewed · How we verify
NCT07142603
Appetite Response to Meals With Different Protein Sources in Women With PCOS
NA trial testing Metabolic response to protein source in Polycystic Ovary Syndrome (PCOS) in 30 participants. Currently enrolling.
31 December 2026
Quick facts
| Lead sponsor | University of Arkansas, Fayetteville |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | single |
| Primary purpose | basic science |
| Enrollment | 30 |
| Start date | 18 August 2025 |
| Primary completion | 31 December 2026 |
| Estimated completion | 30 June 2027 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Metabolic response to protein source
Conditions studied
- Polycystic Ovary Syndrome (PCOS) — all drugs for Polycystic Ovary Syndrome (PCOS) →
Sponsor
University of Arkansas, Fayetteville
Who can join
Adults 18 to 50, female only, with Polycystic Ovary Syndrome (PCOS). Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Polycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by insulin resistance, hyperandrogenism, and reproductive dysfunction. Dietary strategies that improve postprandial insulin and glucose responses are central to managing metabolic symptoms in PCOS. Meals higher in protein can attenuate postprandial glycemia and enhance satiety, but the effects may vary by protein source. Animal sources of protein typically have higher essential amino acid content and insulinogenic potential, whereas plant proteins offer fiber and phytochemicals that may influence glycemic dynamics differently. Few studies have directly compared the acute metabolic effects of plant versus animal protein in women with PCOS. Given the distinct pathophysiology of PCOS, extrapolating findings from healthy populations may be misleading. Understanding protein-specific effects on postprandial insulin, glucose, and appetite-regulating hormones in this group is essential for targeted nutrition guidance. Additionally, plant-based diets are increasingly promoted for cardiometabolic health, but their acute effects in insulin-resistant women remain underexplored. This study will assess whether plant and animal protein meals elicit differential postprandial responses in women with PCOS. Findings may inform dietary recommendations aimed at improving metabolic outcomes in this high-risk population.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07142603
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Polycystic Ovary Syndrome (PCOS)
Currently open trials in the same condition.
- NCT07298564 — Effect of Magnesium and Levocarnitine on Metabolic and Clinical Outcomes in Women With Polycystic Ovarian Syndrome (PCOS · NA · recruiting
- NCT07394530 — Comparison of IVF Outcomes Between PPOS and Antagonist Protocols in Women With PCOS · NA · recruiting
- NCT07371364 — Mobile Application for Women With Polycystic Ovary Syndrome · NA · active not recruiting
- NCT07242131 — Efficacy of Oral Contraceptive, Progesterone, and Inositol on Menstrual Regulation in PCOS · NA · recruiting
- NCT07171970 — IVM - Fresh ET (THE SAIGON PROTOCOL) Versus IVF - FET in PCOS Women · NA · recruiting
Other University of Arkansas, Fayetteville trials
Trials by the same sponsor.
- NCT07158723 — Protein and Polycystic Ovary Syndrome (PCOS) · NA · recruiting
- NCT07490756 — Methods of Assessing Sweat-Electrolyte Testing (MAST) · NA · completed
- NCT06849817 — Protein and Exercise for Postmenopausal Women's Wellbeing · NA · recruiting
- NCT06915415 — Comparison Between a Live Canine or Toy Dog on Prosocial Behavior and Emotional Regulation in Autistic Children · NA · completed
- NCT06687850 — Animal-Assisted Therapy in Pediatric Autism Spectrum Disorders · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07142603 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Arkansas, Fayetteville
- Last refreshed: 2 September 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07142603.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing