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NCT07134283
Effect of Preoperative Cold Therapy on Early Postoperative Outcomes in Total Knee Arthroplasty
NA trial testing Preoperative and Postoperative Cold Therapy with Gel Cold Pack in Knee Osteoarthritis in 208 participants. Completed in 1 August 2025.
30 July 2025
Quick facts
| Lead sponsor | Ankara City Hospital Bilkent |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 208 |
| Start date | 10 June 2024 |
| Primary completion | 30 July 2025 |
| Estimated completion | 1 August 2025 |
| Sites | 1 location across Turkey (Türkiye) |
Drugs / interventions tested
- Preoperative and Postoperative Cold Therapy with Gel Cold Pack
- Postoperative Cold Therapy with Gel Cold Pack
Conditions studied
- Knee Osteoarthritis — all drugs for Knee Osteoarthritis →
- Total Knee Arthroplasty — all drugs for Total Knee Arthroplasty →
- Cryotherapy — all drugs for Cryotherapy →
- Postoperative Pain Management — all drugs for Postoperative Pain Management →
Sponsor
Ankara City Hospital Bilkent
Who can join
55 and older, any sex, with Knee Osteoarthritis or Total Knee Arthroplasty. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This prospective, single-center, randomized controlled trial investigates the effects of preoperative cold therapy on early postoperative outcomes in patients undergoing unilateral primary total knee arthroplasty (TKA). A total of 208 patients were randomized into two groups: one receiving conventional cold therapy preoperatively and postoperatively, and the other receiving only routine postoperative cold therapy. Primary outcomes included postoperative pain (VAS), edema (thigh circumference), hemoglobin levels, drainage volume, opioid usage, Knee Society Scores (KSS), and presence of ecchymosis. The study demonstrated that initiating cold therapy before surgery significantly reduced postoperative drainage and opioid requirement, and delayed early edema progression. These findings suggest that the timing of cold therapy may influence recovery, highlighting a potentially beneficial approach to perioperative care in TKA.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT07134283
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Other Ankara City Hospital Bilkent trials
Trials by the same sponsor.
- NCT07496788 — Investigation of the Role of Internal Jugular Vein Collapsibility Index in Predicting Spinal Anesthesia-Induced Hypotens · not yet recruiting
- NCT07536464 — PEEP Strategies and Mechanical Power in Robotic Surgery · NA · not yet recruiting
- NCT07534553 — Mechanical Power Ventilation in RALP · NA · not yet recruiting
- NCT07501468 — Ventilation Safety in Beach Chair Shoulder Surgery: SafeLM Versus I-gel · NA · not yet recruiting
- NCT07502209 — Suprascapular Nerve PRF in Chronic Shoulder Pain · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07134283 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Ankara City Hospital Bilkent
- Last refreshed: 21 August 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07134283.
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