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NCT07131800: VOICE
Objective and Perceptual Characteristics of the Voice After Endotracheal Intubation in Head and Neck Surgery
trial in Voice Disorder Due to Iatrogenic Factor in 180 participants. Enrolling by invitation.
31 December 2025
Quick facts
| Lead sponsor | Clinical Hospital Centre Zagreb |
|---|---|
| Status | ENROLLING BY INVITATION |
| Study type | OBSERVATIONAL |
| Enrollment | 180 |
| Start date | 25 September 2024 |
| Primary completion | 31 December 2025 |
| Estimated completion | 30 March 2026 |
| Sites | 1 location across Croatia |
Conditions studied
- Voice Disorder Due to Iatrogenic Factor — all drugs for Voice Disorder Due to Iatrogenic Factor →
- Endotracheal Intubation During Surgery — all drugs for Endotracheal Intubation During Surgery →
- Thyroid Surgery — all drugs for Thyroid Surgery →
- Head and Neck Surgery — all drugs for Head and Neck Surgery →
Sponsor
Clinical Hospital Centre Zagreb
Who can join
Adults 18 to 70, any sex, with Voice Disorder Due to Iatrogenic Factor or Endotracheal Intubation During Surgery. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Introduction: Possible consequences of endotracheal intubation are post-intubation voice changes. Hypothesis: Endotracheal intubation during head and neck surgery is associated with objective and perceptual voice disorders. Research objective: To investigate the short-term and long-term effects of endotracheal intubation on voice quality during head and neck surgery. Material, subjects, methodology and research design: A prospective observational cohort study that will include patients undergoing surgery and endotracheal intubation lasting up to 3 hours. Adult patients divided into three groups will be included in the research: thyroid surgery, parotid gland surgery and abdominal surgery. Videostroboscopy, perceptual and objective acoustic voice analysis will be recorded before surgery, on the second postoperative day, two weeks and 1 month after surgery. Expected scientific contribution of the proposed research: The scientific contribution would be an understanding of the risk factors and the connection of voice disorders after endotracheal intubation, as well as the ability to determine differences in this risk in patients undergoing different operations.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07131800 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Clinical Hospital Centre Zagreb
- Last refreshed: 20 August 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07131800.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing