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NCT07131748: HExOLD
Effect of Heated Water-Based Versus Land-Based Exercise Training on Hemodynamic Variables, Functional Capacity and Quality of Life in Older Hypertensive
NA trial testing Physical Exercise Session in heated Swimming Pool - HEx in Hypertension in 60 participants. Currently enrolling.
30 August 2027
Quick facts
| Lead sponsor | Universidade Estadual Paulista Júlio de Mesquita Filho |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | supportive care |
| Enrollment | 60 |
| Start date | 1 September 2025 |
| Primary completion | 30 August 2027 |
| Estimated completion | 30 August 2027 |
| Sites | 1 location across Brazil |
Drugs / interventions tested
- Physical Exercise Session in heated Swimming Pool - HEx
- Physical Exercise Session in Land- LEx
- Control Session Without Exercise- CON
Conditions studied
- Hypertension — all drugs for Hypertension →
- Aging — all drugs for Aging →
- Exercise — all drugs for Exercise →
Sponsor
Universidade Estadual Paulista Júlio de Mesquita Filho — full company profile →
Who can join
60 and older, any sex, with Hypertension or Aging. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
BACKGROUND: Physical exercise promotion is one of the main global goals of innumerous health and medical societies for preventing and managing noncommunicable chronic diseases (NCDs), being one of the main therapeutic for the patient with hypertension. Exercise in heated swimming pool has emerged as a potential alternative to physical exercise on the ground for the reduction of blood pressure (BP) of hypertensive patients, however, its effects on BP, as well as hemodynamic, metabolic, inflammatory and functional variables of older individuals with hypertension have not been investigated. PURPOSE: To evaluate the effects of heated water-based exercise (HEx) versus land-based exercise (LEx) on BP, arterial stiffness, endothelial function, metabolic, inflammatory and functional variables of older individuals with hypertension. METHODS: 60 older individuals (male and female) with hypertension (age \> 60 years) will be randomized in 2:2:1 ratio to HEx, LEx or control (CON) intervention. The feasibility and physiological adaptations (physical capacity, musculoskeletal and cardiovascular responses to stress, biological and biochemical markers associated with the pathophysiology of the disease and vascular adaptations) will be assessed before, after 12 weeks and after 24 weeks of follow-up. HEx and LEx training programs will be performed three times per week and will be performed for the firs 12 weeks of follow-up.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07131748
- Europe PMC full search
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Other Universidade Estadual Paulista Júlio de Mesquita Filho trials
Trials by the same sponsor.
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- NCT06405477 — EFFECTS OF L-ARGININE SUPPLEMENTATION ON THE RECOVERY OF CARDIORESPIRATORY PARAMETERS AFTER SUBMAXIMAL EXERCISE TEST · NA · recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07131748 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Universidade Estadual Paulista Júlio de Mesquita Filho
- Last refreshed: 20 August 2025
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