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NCT07130110
BAL Contribution to Lung Cryo-TBB in ILD
NA trial testing Transbronchial cryobiopsy in Bronchoalveolar Lavage (BAL) in 127 participants. Completed in 30 September 2024.
21 June 2024
Quick facts
| Lead sponsor | Saglik Bilimleri Universitesi |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | diagnostic |
| Enrollment | 127 |
| Start date | 20 December 2023 |
| Primary completion | 21 June 2024 |
| Estimated completion | 30 September 2024 |
| Sites | 1 location across Turkey (Türkiye) |
Drugs / interventions tested
- Transbronchial cryobiopsy
- Bronchoalveolar Lavage — full drug profile →
Conditions studied
- Bronchoalveolar Lavage (BAL) — all drugs for Bronchoalveolar Lavage (BAL) →
- Transbronchial Cryobiopsy — all drugs for Transbronchial Cryobiopsy →
- Interstitial Lung Disease (ILD) — all drugs for Interstitial Lung Disease (ILD) →
Sponsor
Saglik Bilimleri Universitesi — full company profile →
Who can join
Adults 19 to 79, any sex, with Bronchoalveolar Lavage (BAL) or Transbronchial Cryobiopsy. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this observational study is to evaluate whether performing bronchoalveolar lavage (BAL) simultaneously with transbronchial lung cryobiopsy (c-TBB) can improve diagnostic yield in adult patients with suspected interstitial lung disease (ILD). The main questions it aims to answer are: * Does the addition of BAL to c-TBB increase the overall diagnostic accuracy in ILD patients? * Can the combination of BAL and c-TBB reduce the need for surgical lung biopsy in the diagnostic process of ILD? If there is a comparison group: Researchers will compare patients diagnosed by c-TBB alone to those evaluated with both c-TBB and BAL to see if BAL provides additional diagnostic value, especially in cases where histopathological findings from c-TBB are inconclusive. Participants will: Undergo transbronchial lung cryobiopsy (c-TBB) under general anesthesia to collect lung tissue samples. Have bronchoalveolar lavage (BAL) performed in the same session using ATS guideline-based protocols. Be evaluated in a multidisciplinary discussion (MDD) integrating clinical, radiologic, and pathologic findings to establish a final diagnosis.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
The diagnostic contribution of bronchoalveolar lavage to lung cryo-transbronchial biopsy in interstitial lung diseases.
İlhan U, Demirkol B, Turan D, Chousein EU, et al · · 2025 · PMID 41423605 · DOI 10.1186/s12890-025-04059-0
Verify or expand the search:
- PubMed search for NCT07130110
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Transbronchial cryobiopsy
Trials testing the same drug.
- NCT05046093 — Clinical Outcomes of Cryobiopsy for Peripheral Pulmonary Lesions - A Prospective Pilot Study · NA · completed
- NCT03704233 — The Diagnostic Yield and Safety of Transbronchial Cryobiopsy in Diffuse Parenchymal Lung Diseases · unknown
Other recruiting trials for Bronchoalveolar Lavage (BAL)
Currently open trials in the same condition.
- NCT06815666 — BAL Fluid Biomarkers in Sarcoma · Phase 2 · recruiting
Other Saglik Bilimleri Universitesi trials
Trials by the same sponsor.
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- NCT07528001 — Hypno-Breastfeeding Education and Postpartum Outcomes · NA · not yet recruiting
- NCT07344649 — Turkish Validation of the Nijmegen Questionnaire in COPD · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07130110 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Saglik Bilimleri Universitesi
- Last refreshed: 19 August 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07130110.
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