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NCT07127744
Relationship Between Malocclusion Severity and Periodontitis Risk
trial in Malocclusion in 70 participants. Not yet recruiting.
15 December 2025
Quick facts
| Lead sponsor | Recep Tayyip Erdogan University Training and Research Hospital |
|---|---|
| Status | Not yet recruiting |
| Study type | OBSERVATIONAL |
| Enrollment | 70 |
| Start date | 15 September 2025 |
| Primary completion | 15 December 2025 |
| Estimated completion | 19 January 2026 |
| Sites | 1 location across Turkey (Türkiye) |
Conditions studied
- Malocclusion — all drugs for Malocclusion →
Sponsor
Recep Tayyip Erdogan University Training and Research Hospital
Who can join
Adults 12 to 18, any sex, with Malocclusion. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this observational study is to examine the potential relationship between the severity of orthodontic malocclusion and the risk of developing periodontitis in individuals by evaluating salivary and gingival crevicular levels of RANKL, osteoprotegerin (OPG), and oxidative stress biomarkers. The main question it aims to answer is: Does increasing severity of orthodontic malocclusion contribute to a higher risk of periodontitis through changes in RANKL/OPG balance and oxidative stress levels? Participants with different levels of tooth misalignment (malocclusion) will be examined to assess the condition of their teeth and gums. During this examination, information such as dental plaque, gum bleeding, and the depth of gum pockets will be recorded. In addition, fluid samples collected from the gums will be tested in the laboratory to measure certain biological substances and chemical markers related to the body's balance between harmful and protective effects. These measurements will be done using special laboratory tests.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07127744
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Related trials
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Other Recep Tayyip Erdogan University Training and Research Hospital trials
Trials by the same sponsor.
- NCT07427095 — The Relationship Between Ultra-Processed Food Consumption and Oral Health · not yet recruiting
- NCT07427069 — Chronic Kidney Disease Associated Diet · not yet recruiting
- NCT07462104 — Metabolic Syndrome Associated Diet · not yet recruiting
- NCT07354815 — Metabolic Syndrome-Associated Periodontal Inflammatory Surface Area · not yet recruiting
- NCT07287540 — Anti-inflammatory Nutrition on the Outcomes of Non-surgical Periodontal Therapy · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07127744 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Recep Tayyip Erdogan University Training and Research Hospital
- Last refreshed: 22 August 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07127744.
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