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NCT07127471
Computer-Aided Water Exchange Colonoscopy With and Without Linked-Color Imaging for Detection of Clinically Significant Serrated Lesions
NA trial testing Water exchange with AI-assisted detection in Sessile Colonic Polyp in 1,090 participants. Currently enrolling.
30 April 2027
Quick facts
| Lead sponsor | Evergreen General Hospital, Taiwan |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | screening |
| Enrollment | 1,090 |
| Start date | 17 November 2025 |
| Primary completion | 30 April 2027 |
| Estimated completion | 31 July 2027 |
| Sites | 4 locations across Italy, Canada, Thailand, Taiwan |
Drugs / interventions tested
- Water exchange with AI-assisted detection
- Water exchange with AI-assisted detection and LCI
Conditions studied
- Sessile Colonic Polyp — all drugs for Sessile Colonic Polyp →
- Serrated Lesion — all drugs for Serrated Lesion →
- Sessile Serrated Lesion — all drugs for Sessile Serrated Lesion →
- Colon Adenomas — all drugs for Colon Adenomas →
Sponsor
Evergreen General Hospital, Taiwan
Who can join
Adults 40 to 80, any sex, with Sessile Colonic Polyp or Serrated Lesion. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this clinical trial is to compare the detection rate of clinically significant serrated lesions (CSSL) in participants undergoing water exchange (WE) colonoscopy with artificial intelligence (AI)-based computer-aided detection (CADe) for screening, surveillance, diagnosis for symptoms, or referred owing to a positive fecal immunochemical test (FIT) or guaiac fecal occult blood test (gFOBT) result. There will be two arms in this study: WE with AI-assisted CADe (WEAID) control and WEAID plus linked-color imaging (LCI). The main question it aims to answer is whether the addition of LCI into WEAID colonoscopy increases CSSL detection rate. Both groups use water instead of air to insert the colonoscope into the cecum. The control method uses CADe to help detect colonic lesions. The study method uses a combination of CADe and LCI to detect lesions. Researchers will compare CSSL detection rate to see if the addition of LCI increases the detection of CSSL during CADe-assisted WE colonoscopy.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07127471
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Sessile Colonic Polyp
Currently open trials in the same condition.
- NCT06286956 — Rectal Tumor Resection Using the UNI-VEC Multichannel Transanal Access Device · NA · active not recruiting
Other Evergreen General Hospital, Taiwan trials
Trials by the same sponsor.
- NCT06496958 — Water Exchange and CO2 Insufflation With Abdominal Compression Device to Reduce Manual Assistance · NA · recruiting
- NCT06173258 — Water Exchange Colonoscopy With Artificial Intelligence-assisted Detection · NA · completed
- NCT05125939 — Can Overall Adenoma Detection Rate Replace Screening Adenoma Detection Rate ? Multicenter Study · recruiting
- NCT04769739 — Dose the Saline Reduce the Mucus Production When Water Exchange Colonoscopy is Used? · NA · completed
- NCT04124393 — Multicenter Evaluation of Right Colon Polyp Miss Rates Using Water Exchange Versus CO2 Insufflation · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07127471 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Evergreen General Hospital, Taiwan
- Last refreshed: 20 November 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07127471.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing