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NCT07125586: REDENP
Real-Time Diagnosis of Eosinophilic Nasal Polyps Using High-Sensitivity Spectroscopy
NA trial testing High-Sensitivity Spectroscopy with Autofluorescence for eCRSwNP Diagnosis in Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) in 353 participants. Currently enrolling.
1 January 2028
Quick facts
| Lead sponsor | The Affiliated Hospital of Qingdao University |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | diagnostic |
| Enrollment | 353 |
| Start date | 26 August 2025 |
| Primary completion | 1 January 2028 |
| Estimated completion | 1 June 2028 |
| Sites | 1 location across China |
Drugs / interventions tested
- High-Sensitivity Spectroscopy with Autofluorescence for eCRSwNP Diagnosis
Conditions studied
- Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) — all drugs for Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) →
Sponsor
The Affiliated Hospital of Qingdao University
Who can join
Adults 18 to 65, any sex, with Chronic Rhinosinusitis With Nasal Polyps (CRSwNP). Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common condition causing nasal congestion, discharge, and reduced sense of smell, seriously affecting patients' quality of life. A subtype called eosinophilic CRSwNP (eCRSwNP) is difficult to treat and often recurs after surgery. Currently, diagnosing this subtype requires tissue samples after surgery, which delays treatment decisions and may lead to unnecessary surgeries. Our research team has developed a new, non-invasive diagnostic system using advanced spectral technology to detect a natural fluorescence marker inside eosinophils (a type of immune cell) in nasal polyps. This system can quickly identify eCRSwNP before surgery by shining a safe light on the nasal tissue and analyzing the fluorescence signals. This study aims to evaluate how accurate and safe this real-time diagnostic system is in clinical practice. If successful, it will help doctors choose better personalized treatments, reduce unnecessary surgeries, lower recurrence rates, and ultimately improve patients' lives.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07125586
- Europe PMC full search
- ASCO Meeting Library
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Related trials
Other recruiting trials for Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
Currently open trials in the same condition.
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Other The Affiliated Hospital of Qingdao University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07125586 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by The Affiliated Hospital of Qingdao University
- Last refreshed: 30 December 2025
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