NCT07125105: APART-MG

Integrating Art Therapy and Adapted Physical Activity: Toward Improved Quality of Life in Patients With Myasthenia Gravis

Not yet recruiting NA Last updated 15 August 2025

What this trial tests

NA trial testing Adapted Physical Activity Only in Myasthenia Gravis in 102 participants. Not yet recruiting.

Timeline

1 November 2025

Primary endpoint
30 April 2028

30 October 2028

Quick facts

Lead sponsor	Universite du Littoral Cote d'Opale
Phase	NA
Status	Not yet recruiting
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	single
Primary purpose	treatment
Enrollment	102
Start date	1 November 2025
Primary completion	30 April 2028
Estimated completion	30 October 2028
Sites	1 location across France

Drugs / interventions tested

• Adapted Physical Activity Only
• Adapted Physical Activity + Art Therapy

Conditions studied

• Myasthenia Gravis — all drugs for Myasthenia Gravis →

Sponsor

Universite du Littoral Cote d'Opale

Who can join

18 and older, any sex, with Myasthenia Gravis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Myasthenia Gravis (MG) is a rare neuromuscular disease characterized by fluctuating muscle weakness and excessive fatigability. Although medical treatments have improved, MG continues to significantly impact patients' physical, emotional, and social well-being. Current care primarily focuses on symptom management, often overlooking the broader psychosocial needs of patients.

This study explores an innovative and holistic approach combining Adapted Physical Activity (APA) and Art Therapy (AT) to improve quality of life in adults with MG. The intervention includes two 6-week phases in a crossover design: one with APA alone and one combining APA with personalized AT sessions focused on body awareness, movement, and creative expression.

The investigators hypothesize that the addition of AT to a standardized APA program will significantly enhance patients' engagement and well-being, resulting in improved quality of life, reduced fatigue, and better mental health outcomes.

A total of 102 adult participants will be recruited from several hospitals in northern France (Lille, Dunkerque, Calais, Boulogne-sur-Mer, and Saint-Omer). Participants will be randomly assigned to begin with either APA alone or APA+AT. All interventions are tailored to the specific needs of MG patients and will be delivered both in person and online, depending on participant needs.

Outcomes will be evaluated using standardized questionnaires (e.g., MG-QOL15, FSS, HADS), physical performance tests (e.g., handgrip strength, sit-to-stand), and accelerometry. Qualitative data will be collected through semi-structured interviews, ethnographic observations and art based research to better understand patients' experiences.

The study has received ethical approval from the French National Ethics Committee (CPP) and involves minimal risk. Participation is voluntary, with no financial compensation. This protocol may pave the way for broader application of APA+AT models in other rare or chronic conditions that involve fluctuating fatigue and psychosocial complexity.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Combined adapted physical activity and art-therapy intervention in myasthenia gravis: Study protocol for a randomized crossover pilot trial.
   Leclercq C, Archer A, Ceccone F, Davion JB, et al · · 2026 · PMID 41720335 · DOI 10.1016/j.cct.2026.108260