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NCT07117006: AOB-Mx_INT-MS
Anterior Open Bite Closure by Clear Aligners Versus Fixed Appliances in Adult Patients With Skeletal Open Bite: A Randomized Clinical Trial.
NA trial testing miniscrew- supported maxillary posterior segments' intrusion using clear aligners in Skeletal Open Bite in 8 participants. Participants enrolled and being followed up; not accepting new ones.
30 December 2025
Quick facts
| Lead sponsor | Cairo University |
|---|---|
| Phase | NA |
| Status | Active, enrolled |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 8 |
| Start date | 30 December 2024 |
| Primary completion | 30 December 2025 |
| Estimated completion | 1 February 2026 |
| Sites | 1 location across Egypt |
Drugs / interventions tested
- miniscrew- supported maxillary posterior segments' intrusion using clear aligners
Conditions studied
- Skeletal Open Bite — all drugs for Skeletal Open Bite →
- Open Bite — all drugs for Open Bite →
- Maxillary Intrusion — all drugs for Maxillary Intrusion →
- Mini-screws — all drugs for Mini-screws →
Sponsor
Cairo University
Who can join
Eligibility, any sex, with Skeletal Open Bite or Open Bite. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Here's a 1,000-word (quarter-length) concise version of your research brief, preserving the key structure and essential details: Brief Summary: Comparative Management of Skeletal Anterior Open Bite Using Mini-Screw Supported Intrusion with Clear Aligners Versus Fixed Appliances PICO elements Population: Adults (17-25 years) with uncompensated skeletal anterior open bite. Intervention: TAD-supported intrusion with clear aligners. Comparison: TAD-supported intrusion with fixed appliances. Outcomes: Primary: Anterior open bite closure. Secondary: Molar intrusion, mandibular autorotation, incisor movement and quality of life.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07117006
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07117006 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Cairo University
- Last refreshed: 12 August 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07117006.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing