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NCT07110324: PAIN-COMPO
Characteristics of Persistent Pain Composition Following Total Hip or Knee Arthroplasty: a Descriptive Study
trial in Pain (Visceral, Somatic, or Neuropathic) in 100 participants. Currently enrolling.
1 December 2026
Quick facts
| Lead sponsor | Rigshospitalet, Denmark |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 100 |
| Start date | 26 June 2025 |
| Primary completion | 1 December 2026 |
| Estimated completion | 1 December 2026 |
| Sites | 1 location across Denmark |
Conditions studied
- Pain (Visceral, Somatic, or Neuropathic) — all drugs for Pain (Visceral, Somatic, or Neuropathic) →
- Hip Arthroplasty Replacement — all drugs for Hip Arthroplasty Replacement →
- Knee Arthroplasty, Total — all drugs for Knee Arthroplasty, Total →
- Survey and Questionnaire — all drugs for Survey and Questionnaire →
Sponsor
Rigshospitalet, Denmark
Who can join
18 and older, any sex, with Pain (Visceral, Somatic, or Neuropathic) or Hip Arthroplasty Replacement. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Despite high success rates of hip and knee arthroplasty, up to 20% of patients report moderate-to-severe pain (NRS \> 3) persisting beyond the expected healing period. This investigator-initiated, descriptive cohort study will re-invite approximately 100 consenting patients with persistent postoperative pain-identified from a pool of \~7 000 respondents-to complete standardized assessments of neuropathic (DN4), nociplastic (IASP criteria + Fibromyalgia Survey Questionnaire) and nociceptive (KOOS/HOOS pain domains) pain. Primary outcomes are the prevalence of potential nociplastic pain and the proportion experiencing significant pain in two or more mechanistic categories. Secondary analyses will compare baseline vs. re-evaluated DN4 scores, FSQ and KOOS/HOOS distributions, and examine differences between patients with and without possible neuropathic pain. Findings will inform targeted pre- and postoperative pain management strategies.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07110324
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Currently open trials in the same condition.
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Other Rigshospitalet, Denmark trials
Trials by the same sponsor.
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- NCT07511439 — Reversible Effects of Oral Contraceptive Removal on Serotonergic Neurotransmission · Phase 4 · not yet recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07110324 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Rigshospitalet, Denmark
- Last refreshed: 1 April 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07110324.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing