Last reviewed · How we verify
NCT07103616: ICHOR
Individual Cerebral Hemodynamic Oxygenation Relationships - ICHOR 4
Phase 4 trial testing Randomization of Propofol or Dexmedetomidine in Anesthesia; Reaction in 130 participants. Not yet recruiting.
1 September 2028
Quick facts
| Lead sponsor | Children's Hospital Los Angeles |
|---|---|
| Phase | Phase 4 |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | basic science |
| Enrollment | 130 |
| Start date | 1 September 2025 |
| Primary completion | 1 September 2028 |
| Estimated completion | 1 September 2028 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Randomization of Propofol or Dexmedetomidine — full drug profile →
Conditions studied
- Anesthesia; Reaction — all drugs for Anesthesia; Reaction →
- Anesthesia — all drugs for Anesthesia →
Sponsor
Children's Hospital Los Angeles
Who can join
Under 7, any sex, with Anesthesia; Reaction or Anesthesia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this clinical trial is to understand whether there are differences in the cerebral blood flow, and oxygen metabolism affected by two types of anesthesia: Propofol or Dexmedetomidine. Subjects who require clinical anesthesia for a clinical MRI and for whom the use of Propofol and Dexmedetomidine are in clinical equipoise will be offered to have the anesthesia they will receive during their MRI randomized. * Change in cerebral blood flow (ml blood/100g/min) * Change in cerebral metabolic rate of oxygen (ml O2/100g/min) Researchers will compare Propofol (Group A) to Dexmedetomidine (Group B) to see if compare the hemodynamic response to anesthesia. Participants will be randomized to receive one of two equally safe anesthetics (Propofol or Dexmedetomidine).
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07103616
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Anesthesia; Reaction
Currently open trials in the same condition.
- NCT03839784 — Building a Platform for Precision Anesthesia in the Geriatric Surgical Patient · recruiting
- NCT04435834 — Individual Cerebral Hemodynamic Oxygenation Relationships · Phase 4 · recruiting
Other Children's Hospital Los Angeles trials
Trials by the same sponsor.
- NCT07064824 — Adaptive Cell Phone Support (ACPS) · NA · not yet recruiting
- NCT07508436 — Crisis Interventions for Pediatric Providers - Autism Version · NA · not yet recruiting
- NCT06934655 — Early Re-Initiation of Semaglutide Post Sleeve Gastrectomy in Youth · Phase 3 · not yet recruiting
- NCT07427862 — Virtual Reality (VR) for Interventional Radiology (IR) Procedures · recruiting
- NCT07213908 — Comparing Two School-Based Sleep Health Interventions To Promote Sleep Quality in Youth · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07103616 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Children's Hospital Los Angeles
- Last refreshed: 5 August 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07103616.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing