Last reviewed · How we verify
NCT07103317: CoroPhys-CZ
Comprehensive Coronary Physiology in Patients With Angina With Nonobstructive Coronary Arteries - Czech Republic
trial in ANOCA in 1,000 participants. Currently enrolling.
1 January 2027
Quick facts
| Lead sponsor | University Hospital, Motol |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 1,000 |
| Start date | 20 April 2023 |
| Primary completion | 1 January 2027 |
| Estimated completion | 1 January 2030 |
| Sites | 1 location across Czechia |
Conditions studied
- ANOCA — all drugs for ANOCA →
- ANOCA - Angina With Non-obstructive Coronary Arteries — all drugs for ANOCA - Angina With Non-obstructive Coronary Arteries →
- MINOCA — all drugs for MINOCA →
- Microvascular Dysfunction — all drugs for Microvascular Dysfunction →
Sponsor
University Hospital, Motol
Who can join
18 and older, any sex, with ANOCA or ANOCA - Angina With Non-obstructive Coronary Arteries. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Coronary artery disease (CAD) is a leading cause of morbidity and mortality. While cardiologists have been focused on discrete, visible stenoses of coronary arteries, there is increasing awareness of the importance of microcirculation and vasospastic disorders in causing angina. The microvascular bed is composed of vessels smaller than 400 microns in diameter. Their network is significantly larger than that of the epicardial vessels and serves essential functions, including regulating myocardial blood flow and cellular metabolism. Angina pectoris, a most frequent symptom of CAD or myocardial ischemia, was assumed to be caused by significant stenosis of the epicardial coronary artery. However, it was found that in over 50% of cases, there was no obstructive CAD, which is described as angina with no obstructive coronary arteries (ANOCA) or ischemia with no obstructive coronary arteries (INOCA), according to the clinical setting.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07103317
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07103317 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Hospital, Motol
- Last refreshed: 5 August 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07103317.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing