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NCT07101003
A Comparative Evaluation of the Degree of Pain and MMP-9 Expression Following Instrumentation of Necrotic Pulps With Apical Periodontitis in One or Two Visits
NA trial testing single visit instrumentation in Apical Periodontitis in 28 participants. Not yet recruiting.
1 August 2025
Quick facts
| Lead sponsor | Marwa Hisham Mohamed Salah Eldin |
|---|---|
| Phase | NA |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 28 |
| Start date | 1 August 2025 |
| Primary completion | 1 August 2025 |
| Estimated completion | 4 August 2025 |
Drugs / interventions tested
- single visit instrumentation
- multiple visit instrumentation
Conditions studied
- Apical Periodontitis — all drugs for Apical Periodontitis →
- Necrotic Pulps — all drugs for Necrotic Pulps →
- Single Rooted Teeth — all drugs for Single Rooted Teeth →
Sponsor
Marwa Hisham Mohamed Salah Eldin
Who can join
Adults 18 to 40, any sex, with Apical Periodontitis or Necrotic Pulps. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This randomized clinical trial compares postoperative pain and MMP-9 levels after root canal treatment of necrotic teeth with apical periodontitis, using either single-visit or two-visit instrumentation. The primary outcome is pain intensity measured at multiple intervals using a Visual Analogue Scale. The secondary outcome is the periapical expression of MMP-9 assessed via ELISA. The trial aims to determine whether treatment timing impacts inflammation and healing.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07101003
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Apical Periodontitis
Currently open trials in the same condition.
- NCT07237620 — The Effect of Different Intracanal Medicaments on Periapical Lesion Healing · NA · recruiting
- NCT07307807 — Evaluation of Postoperative Pain and Lesion Healing in Periapical Lesion-Affected Teeth Obturated With Different Root Ca · NA · active not recruiting
- NCT06843525 — Bite Force Measurements · recruiting
- NCT07048028 — Chitosan Irrigation in Premolar Root Canal Therapy (Randomized Trial) · NA · recruiting
- NCT07448571 — Evaluation of Revitalization Success Using i-PRF in Non-Surgical Root Canal Retreatment · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07101003 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Marwa Hisham Mohamed Salah Eldin
- Last refreshed: 3 August 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07101003.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing