NCT07079501

Eye Cream 8-Week Efficacy Clinical Study

Completed NA Last updated 23 July 2025

What this trial tests

NA trial testing Test Eye Cream (Formula# 899675 44A) in Wrinkles and Rhytides in 50 participants. Completed in 28 March 2025.

Timeline

17 November 2024

Primary endpoint
14 February 2025

28 March 2025

Quick facts

Lead sponsor	ChinaNorm
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	50
Start date	17 November 2024
Primary completion	14 February 2025
Estimated completion	28 March 2025
Sites	1 location across China

Drugs / interventions tested

• Test Eye Cream (Formula# 899675 44A)

Conditions studied

• Wrinkles and Rhytides — all drugs for Wrinkles and Rhytides →

Sponsor

ChinaNorm

Who can join

Adults 20 to 50, female only, with Wrinkles and Rhytides. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

To investigate efficacy on test cream \[Formula#899675 44A\] on female subjects after 2-week wash-out and 8-week repeated application.

50 female adult subjects will be enrolled in the study, recruited according to inclusion and non-inclusion criteria listed above. At least 40 subjects should complete the study in this 10-week study (wash-out phase for 2-week and treatment phase for 8 weeks). Subjects will need to refrain from using any product other than the provided products on face during the study phase.

1. Clinical Assessment (N=40 at least):

\*Clinical scoring for smoothness (visual), elasticity, cheek plumpness, radiance, global fine lines, firmness, dry lines, small folds on nasolabial zone (Atlas), underneath eye wrinkles (Atlas), forehead wrinkles (Atlas), nasolabial fold (Atlas), cheek folds: (Atlas), wrinkles of the corner of the lips (Atlas), inter-ocular wrinkles (Atlas), crow's feet wrinkles (Atlas), glabellar wrinkles (Atlas), horizontal neck fold (Atlas) by Dermatologist at T-2W, T0, Timm, T2W, T4W, T8W.
* Clinical scoring for eye bag (Atlas), intensity and coverage of dark circle (vascular) (0\~4 scale) by Dermatologist at T-2W, T0, T2W, T4W, T8W.
2. Image Capture and Analysis (N=40 at least):

\*The facial photo will be captured by VISIA CRP (Canfield, Gen 5.0) on left, front and right sides with Standard, Cross-polarized, Parallel-Polarized, Primos operated by trained technician at T0, Timm, T2W, T4W, T8W.

-Demo with mark line for forehead wrinkles, underneath eye wrinkles, crow's feet wrinkles
* Primos demo for crow's feet wrinkles

Image Analysis by Primos 5.8E:

-Wrinkle volume (mm³), Wrinkle area (mm²), total length (mm), count of crow's feet wrinkles

\*The facial photo will be captured by COLORFACE® (Newtone Technologies) on front side with closed eyes under Cross-Polarized mode at T0, T2W, T4W, T8W.
* Demo with dark circles.

Image Analysis by Image-Pro Plus 7.0:
* L\*, a\*, b\* and ITA° focus on underneath eye zone.

\*The local 3D photo will be captured by Primos-lite (Canfield) on both sides of underneath eye zone for eye bags by trained technician at T0, T2W, T4W, T8W. (at least 10 subjects with eye bags (Altas, 0\~6 scale) grade≥2)
* Demo with eye bags.

Image Analysis by Primos 5.8E:

-Rising Volume (mm³) of eye bags

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.