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NCT07069790: PROTECT-08B
Effects of Chemotherapy Treatment on Metaboreflex, Mechanoreflex, and Baroreflex Function: PROTECT-08B Study
NA trial testing Test of neuromuscular fatigue and associated hemodynamic responses in Breast Adenocarcinoma in 24 participants. Currently enrolling.
2 October 2026
Quick facts
| Lead sponsor | Centre Paul Strauss |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | parallel |
| Masking | none |
| Primary purpose | prevention |
| Enrollment | 24 |
| Start date | 2 October 2025 |
| Primary completion | 2 October 2026 |
| Estimated completion | 2 October 2026 |
| Sites | 1 location across France |
Drugs / interventions tested
- Test of neuromuscular fatigue and associated hemodynamic responses
Conditions studied
- Breast Adenocarcinoma — all drugs for Breast Adenocarcinoma →
Sponsor
Centre Paul Strauss — full company profile →
Who can join
18 and older, female only, with Breast Adenocarcinoma. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Breast cancer is the most common cancer worldwide, with over 2.2 million new cases diagnosed in 2020. Treatments such as chemotherapy often lead to a reduced exercise capacity, mainly due to cardiovascular and neuromuscular dysfunctions. This decline appears to be primarily caused by increased central fatigue, while peripheral fatigue remains unchanged. This imbalance suggests a hyperactivation of type III-IV afferent nerve fibers, which are involved in the metaboreflex-a mechanism that significantly influences cardiovascular responses during exercise. Two non-invasive methods, post-exercise circulatory occlusion (PECO) and passive leg movement (PLM), will be used to assess this hyperactivity in patients. Additionally, baroreflex function-crucial for regulating blood pressure-will be evaluated using a direct method to determine its sensitivity and reactivity. By comparing patients with healthy controls under submaximal stimuli, this study aims to better understand chemotherapy-induced cardiovascular dysfunctions. Ultimately, the goal is to design personalized exercise programs to restore cardiovascular function and reduce treatment-related side effects.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07069790
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Test of neuromuscular fatigue and associated hemodynamic responses
Trials testing the same drug.
- NCT06775119 — Feasibility Study of a Neuromuscular Fatigue Test and Associated Hemodynamic Responses: Application in Healthy Volunteer · NA · completed
Other recruiting trials for Breast Adenocarcinoma
Currently open trials in the same condition.
- NCT07122713 — Definitive Radiation Therapy for Inoperable Breast Cancer · NA · recruiting
- NCT07389408 — A Prospective, Multicenter Registry to Observe the Treatment Patterns, Clinical Outcomes, and Decision-Making in Patient · recruiting
- NCT06739655 — Preoperative Radiation Therapy and Immediate Breast Reconstruction · NA · recruiting
- NCT06671262 — Neoadjuvant Toripalimab and Radiotherapy Treatment in N+ HR+ Breast Cancer · Phase 2 · recruiting
- NCT06596018 — Assessing Combined SBRT in Breast Cancer Non-Responders to Neoadjuvant Chemotherapy · Phase 1, PHASE2 · recruiting
Other Centre Paul Strauss trials
Trials by the same sponsor.
- NCT05653635 — Contribution From PET-DOPA in Glioblastoma Re-irradiation - A Randomized Phase II Study · Phase 2 · recruiting
- NCT07204535 — Post-TRaUmatic STress Disorder Induced by Gynecological Brachytherapy · not yet recruiting
- NCT05653622 — Simultaneous Integrated Boost FDOPA Positron Emission Tomography (PET) Guided in Patients With Partially- or Non-operate · Phase 2 · recruiting
- NCT06330142 — Hippotherapy Teenager-pediatric Radiotherapy · NA · recruiting
- NCT06455904 — Effects Of Concentric Cycling Training Protocol During (Neo)Adjuvant Chemotherapy in Breast Cancer Patients: PROTECT-07 · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07069790 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Centre Paul Strauss
- Last refreshed: 31 December 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07069790.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing