NCT07064512

The Effect of Heat Exposure on Physiological Markers

Completed NA Last updated 17 July 2025

What this trial tests

NA trial testing Endogenous heating in Healthy Adult Male in 11 participants. Completed in 12 March 2021.

Timeline

11 January 2021

Primary endpoint
12 March 2021

12 March 2021

Quick facts

Lead sponsor	Lithuanian Sports University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	single
Primary purpose	basic science
Enrollment	11
Start date	11 January 2021
Primary completion	12 March 2021
Estimated completion	12 March 2021
Sites	1 location across Lithuania

Drugs / interventions tested

• Endogenous heating
• Exogenous heating

Conditions studied

• Healthy Adult Male — all drugs for Healthy Adult Male →

Sponsor

Lithuanian Sports University

Who can join

Adults 18 to 36, male only, with Healthy Adult Male. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study is the first to examine the effects of core temperature elevation on kynurenine pathway (KP) metabolites in healthy young males. It was hypothesized that rise in core temperature due to both pasive heating and exercise will initiate a stress response, affecting the concentration of KP metabolites. Additionally, it was expected that the exercise would produce more pronounced effects due to the increased cardiovascular, mechanical, and metabolic demands associated with it. Thus, the the main purpose of the present study was to investigate and to compare the effects of two distinct heat stress modalities on KP metabolites.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Effects of Heat Exposure on Kynurenine Pathway Metabolism-Comparison Between Exertional and Exogenous Heating of the Human Body.
   Louvrou V, Eimantas N, Juškevičiūtė E, Solianik R, et al · · 2025 · cited 2× · PMID 41217979 · DOI 10.1111/apha.70123