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Subanesthetic Esketamine for Hemodynamic Stability and Recovery in Elderly Thoracic Surgery Patients
This retrospective study evaluated the effects of a subanesthetic dose of esketamine (0.25 mg/kg) on intraoperative hemodynamic stability and postoperative recovery quality in elderly patients (aged 65-75) undergoing thoracic surgery under general anesthesia. A total of 230 patients were included and randomly assigned to receive either esketamine or placebo during anesthesia induction. Key outcomes included blood pressure and heart rate stability, catecholamine levels, recovery time, incidence of adverse events such as delirium or nausea, and opioid use.
Details
| Lead sponsor | Hebei Medical University Fourth Hospital |
|---|---|
| Phase | NA |
| Status | COMPLETED |
| Enrolment | 230 |
| Start date | Thu Jun 01 2023 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Sat Nov 30 2024 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- Hemodynamic Instability
- Postoperative Recovery
- Thoracic Surgery
- Anesthesia, General
- Elderly Patients
Interventions
- Esketamine
- Normal Saline (0.9% Sodium Chloride)
- Midazolam
- Sufentanil
- propofol
- Rocuronium
Countries
China