NCT07064304

Er,Cr:YSGG Laser for Deepithelialization in Gingival Recession.

Completed NA Last updated 14 July 2025

What this trial tests

NA trial testing Laser Deepithelialization of Free Gingival Graft in Gingival Recession, Localized in 9 participants. Completed in 31 August 2022.

Timeline

1 February 2021

Primary endpoint
31 August 2022

31 August 2022

Quick facts

Lead sponsor	Wroclaw Medical University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	single
Primary purpose	treatment
Enrollment	9
Start date	1 February 2021
Primary completion	31 August 2022
Estimated completion	31 August 2022
Sites	1 location across Poland

Drugs / interventions tested

• Laser Deepithelialization of Free Gingival Graft
• Scalpel Deepithelialization of Free Gingival Graft

Conditions studied

• Gingival Recession, Localized — all drugs for Gingival Recession, Localized →
• Keratinized Tissue — all drugs for Keratinized Tissue →
• Gingival Thickness — all drugs for Gingival Thickness →
• Pocket Depth — all drugs for Pocket Depth →

Sponsor

Wroclaw Medical University

Who can join

Adults 18 to 70, any sex, with Gingival Recession, Localized or Keratinized Tissue. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Abstract: Introduction: The deepithelialized free gingival graft (DGG) technique provides high-quality connective tissue grafts (CTGs) with predictable outcomes for recession cov-erage. This study evaluates a novel method of free gingival graft (FGG) deepithelialization using an Er,Cr:YSGG laser (LDEE) for treating multiple gingival recessions. Methods: A split-mouth study was conducted on 46 (n=46) recessions in 9 patients (23 per test and control group). Sites were randomized. Full-thickness palatal grafts were harvested with a scalpel. In the test group (LDEE), deepithelialization was performed extraorally using an Er,Cr:YSGG laser (2780 nm; 2.5 W, 83.3 mJ, 30 Hz, 600 µm tip). In the control group (DEE), a 15c scalpel was used. All CTGs were applied using the modified coronally advanced tunnel (TUN) technique. Clinical parameters-recession depth (RD), keratinized tissue width (KT), gingival thickness (GT), pocket depth (PD), clinical attachment loss (CAL), pink esthetic score (PES), approximal plaque index (API), mean root coverage (MRC), and complete root coverage (CRC)-were assessed at baseline (T0), 3 months (T1), and 6 months (T2). Results: Both LDEE and DEE groups showed significant improvements in RD, KT, GT, PD, and CAL over time (p \< 0.001). At T1 and T2, KT was significantly higher in the LDEE group (T1: 3.73±0.72 mm; T2: 3.98±0.76 mm) compared to the DEE group (T1: 3.21±0.61 mm; T2: 3.44±0.74 mm; p \< 0.05). Other parameters (RD, GT, PD, CAL) showed no statistically significant intergroup differences at any time point (p \> 0.05). After 6 months, MRC was 95% and CRC 82.6% for LDEE, compared to 94.8% and 82.6% for DEE (p \> 0.05). PES scores were similar between groups at all time points (p \> 0.05). Conclusion: Both laser- and scalpel-deepithelialized grafts effectively treated gingival recessions. LDEE combined with TUN resulted in significantly greater KT width compared to DEE + TUN.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Clinical Efficacy of Er,Cr:YSGG Laser for Deepithelialization of Free Gingival Grafts in Gingival Recession Treatment: A Randomized, Split-Mouth Clinical Trial.
   Banyś A, Fiegler-Rudol J, Grzech-Leśniak Z, Wiench R, et al · · 2025 · cited 1× · PMID 40806957 · DOI 10.3390/jcm14155335