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NCT07059884: DEFEND
Distance-Based Exercise to Preserve Function and Prevent Disability
NA trial testing Exercise intervention in Hematopoietic and Lymphatic System Neoplasm in 104 participants. Currently enrolling.
1 January 2027
Quick facts
| Lead sponsor | Alliance for Clinical Trials in Oncology |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | supportive care |
| Enrollment | 104 |
| Start date | 11 February 2026 |
| Primary completion | 1 January 2027 |
| Estimated completion | 18 February 2027 |
| Sites | 17 locations across United States |
Drugs / interventions tested
- Exercise intervention
- Telemedicine
- Aerobic Exercise Intervention
- Dumbbell Exercise Intervention
- Accelerometry
- Questionnaire Administration
- Interview
- Electronic Health Record Review
Conditions studied
- Hematopoietic and Lymphatic System Neoplasm — all drugs for Hematopoietic and Lymphatic System Neoplasm →
- Localized Malignant Solid Neoplasm — all drugs for Localized Malignant Solid Neoplasm →
Sponsor
Alliance for Clinical Trials in Oncology
Who can join
18 and older, any sex, with Hematopoietic and Lymphatic System Neoplasm or Localized Malignant Solid Neoplasm. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This clinical trial studies whether an exercise program can be successfully delivered to patients receiving treatment for cancer through virtual sessions and allow patients to exercise in their own home. Treatments for cancer can cause side effects such as fatigue and loss of strength. These side effects can make it difficult to work, take care of family, and do other things the patient wants to do. Preliminary research shows that exercise can help prevent some of these side effects, but it can be more difficult to start an exercise program when a patient is receiving cancer treatment. The exercise program in this study is delivered through telehealth (TH) video calls. The TH sessions are delivered by trained staff that supervise resistance exercises. The trained staff also provide guidance to the patient on completing unsupervised aerobic sessions on their own. This may be a successful way to deliver an exercise program and make it easier for cancer patients to exercise in their own home during treatment.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07059884
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Currently open trials in the same condition.
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Other Alliance for Clinical Trials in Oncology trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07059884 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Alliance for Clinical Trials in Oncology
- Last refreshed: 7 April 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07059884.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing