Osteoarticular Infections on Equipment: Impact of Three Probabilistic Antibiotic Therapy on Digestive Microbiota and Colonization With Multi-resistant Bacteria (HOPE)

NCT07058415 NA NOT_YET_RECRUITING

In the event of suspected osteoarticular material infection (OAMI), broad-spectrum probabilistic antibiotic therapy is recommended immediately after revision surgery. There are no efficacy data to suggest that any particular to favour any particular molecule. However, the choice may depend on the impact on the microbiota and on Enterobacteriaceae colonization with multi-resistant Enterobacteriaceae. Our aim is to evaluate three different strategies efepime+daptomycin C+D, piperacillin-tazobactam+daptomycin (PT+D) and ceftobiprole (CFB).

Details

Lead sponsor	Centre Hospitalier Universitaire de Nice
Phase	NA
Status	NOT_YET_RECRUITING
Enrolment	75
Start date	2025-09
Completion	2027-05

Conditions

• Osteoarticular Material Infection

Interventions

• Stool sample 1
• Stool sample 2
• Stool sample 3

Primary outcomes

• Compare changes in gut microbiota biodiversity between Day1 and Day5 between populations treated with C+D, PT+D and CFB in suspected Osteoarticular infection on equipment — At Day 5 after starting treatment
  using targeted metagenomics (16S rDNA)

Countries

France